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Association between β2-Adrenergic Receptor-16Arg/Gly Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis.

Wang W, Li P, Chen Y, Yang J - Iran. J. Public Health (2014)

Bottom Line: However, the results were inconclusive.Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.More studies with larger sample sizes are needed to validate the results.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Respiratory Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei 430071, China.

ABSTRACT

Background: The association between β2-adrenergic receptor (ADRB2) -16Arg/Gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (COPD) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship.

Methods: The PubMed, EMBASE, ISI web of science, the Cochrane Database of Systematic Reviews, and Chinese databases (CNKI, Wanfang Data, CBM, VIP) were searched for published literature. Odds ratios (OR) with 95% confidence interval (CI) were used to assess the strength of association.

Results: Eleven studies, comprising 1,128 COPD patients and 1,182 controls, were included in the meta-analysis. Overall, there was no significant association between the ADRB2-16Arg/Gly polymorphism and COPD risk in general population. In the stratification analysis by potential confounding variables, significant associations were observed between the ADRB2-16Arg/Gly polymorphism and COPD risk among smoking Asians under the dominant genetic model and allele model (Arg vs. Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.

Conclusion: This meta-analysis suggested that the ADRB2-16Arg/Gly polymorphism might be a potential risk factor for the development of COPD in smoking Asian populations, but not in European descendents, and tobacco smoking probably increased the genetic susceptibility. More studies with larger sample sizes are needed to validate the results.

No MeSH data available.


Related in: MedlinePlus

Begg’s funnel plot for publication bias of studies under dominant model. Each circle represented a corresponding study
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Related In: Results  -  Collection


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Figure 5: Begg’s funnel plot for publication bias of studies under dominant model. Each circle represented a corresponding study

Mentions: A sensitivity analysis was conducted to evaluate the stability of the results by deleting a single study at a time. The results of sensitivity analysis showed that no individual study significantly affected the pooled ORs (Fig.4). Publication bias was estimated by funnel plots Begg’s test and Egger’s test. The funnel plot was almost symmetrical and did not reveal any evidence of publication bias (Fig. 5).


Association between β2-Adrenergic Receptor-16Arg/Gly Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis.

Wang W, Li P, Chen Y, Yang J - Iran. J. Public Health (2014)

Begg’s funnel plot for publication bias of studies under dominant model. Each circle represented a corresponding study
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401053&req=5

Figure 5: Begg’s funnel plot for publication bias of studies under dominant model. Each circle represented a corresponding study
Mentions: A sensitivity analysis was conducted to evaluate the stability of the results by deleting a single study at a time. The results of sensitivity analysis showed that no individual study significantly affected the pooled ORs (Fig.4). Publication bias was estimated by funnel plots Begg’s test and Egger’s test. The funnel plot was almost symmetrical and did not reveal any evidence of publication bias (Fig. 5).

Bottom Line: However, the results were inconclusive.Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.More studies with larger sample sizes are needed to validate the results.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Respiratory Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei 430071, China.

ABSTRACT

Background: The association between β2-adrenergic receptor (ADRB2) -16Arg/Gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (COPD) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship.

Methods: The PubMed, EMBASE, ISI web of science, the Cochrane Database of Systematic Reviews, and Chinese databases (CNKI, Wanfang Data, CBM, VIP) were searched for published literature. Odds ratios (OR) with 95% confidence interval (CI) were used to assess the strength of association.

Results: Eleven studies, comprising 1,128 COPD patients and 1,182 controls, were included in the meta-analysis. Overall, there was no significant association between the ADRB2-16Arg/Gly polymorphism and COPD risk in general population. In the stratification analysis by potential confounding variables, significant associations were observed between the ADRB2-16Arg/Gly polymorphism and COPD risk among smoking Asians under the dominant genetic model and allele model (Arg vs. Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.

Conclusion: This meta-analysis suggested that the ADRB2-16Arg/Gly polymorphism might be a potential risk factor for the development of COPD in smoking Asian populations, but not in European descendents, and tobacco smoking probably increased the genetic susceptibility. More studies with larger sample sizes are needed to validate the results.

No MeSH data available.


Related in: MedlinePlus