Limits...
Association between β2-Adrenergic Receptor-16Arg/Gly Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis.

Wang W, Li P, Chen Y, Yang J - Iran. J. Public Health (2014)

Bottom Line: However, the results were inconclusive.Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.More studies with larger sample sizes are needed to validate the results.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Respiratory Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei 430071, China.

ABSTRACT

Background: The association between β2-adrenergic receptor (ADRB2) -16Arg/Gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (COPD) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship.

Methods: The PubMed, EMBASE, ISI web of science, the Cochrane Database of Systematic Reviews, and Chinese databases (CNKI, Wanfang Data, CBM, VIP) were searched for published literature. Odds ratios (OR) with 95% confidence interval (CI) were used to assess the strength of association.

Results: Eleven studies, comprising 1,128 COPD patients and 1,182 controls, were included in the meta-analysis. Overall, there was no significant association between the ADRB2-16Arg/Gly polymorphism and COPD risk in general population. In the stratification analysis by potential confounding variables, significant associations were observed between the ADRB2-16Arg/Gly polymorphism and COPD risk among smoking Asians under the dominant genetic model and allele model (Arg vs. Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.

Conclusion: This meta-analysis suggested that the ADRB2-16Arg/Gly polymorphism might be a potential risk factor for the development of COPD in smoking Asian populations, but not in European descendents, and tobacco smoking probably increased the genetic susceptibility. More studies with larger sample sizes are needed to validate the results.

No MeSH data available.


Related in: MedlinePlus

Forest plot for the association between ADRB2-16Arg/Gly and COPD risk among smoking Asians under allele and dominant genetic models. (A) dominant model, (B) allele model, fixed-effects model was used
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4401053&req=5

Figure 3: Forest plot for the association between ADRB2-16Arg/Gly and COPD risk among smoking Asians under allele and dominant genetic models. (A) dominant model, (B) allele model, fixed-effects model was used

Mentions: In smoking Asian subgroup, the variant genotypes (Gly/Gly and Arg/Gly) had significant relationship with COPD risk compared with the wild type Arg/Arg homozygote (Gly/Gly vs. Arg/Arg: OR = 0.64, 95% CI = 0.41–0.99, P = 0.153 for heterogeneity, z = 2.01, P = 0.044 for OR; Arg/Gly vs. Arg/Arg: OR = 0.70, 95% CI = 0.50–0.99, P = 0.607 for heterogeneity, z = 1.99, P = 0.046 for OR). Similar results were identified among smoking Asians under the dominant model and allele model (dominant model: OR = 1.45, 95% CI = 1.04–2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03–1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR) (Fig. 3A and B). No statistical association was observed in smoking European descendent subgroup. The stratification analysis by smoking status did not indicate any significant associations, except among undefined smoking populations for recessive model (OR = 0.45, 95% CI = 0.24–0.85, P = 0.389 for heterogeneity, z = 1.28, P = 0.201 for OR). In other subgroups by high-quality score (≥10), ethnicity, study sample size, source of controls and genotyping methods, the OR for each subgroup was not statistically significant. Results have been summarized in Table 3.


Association between β2-Adrenergic Receptor-16Arg/Gly Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis.

Wang W, Li P, Chen Y, Yang J - Iran. J. Public Health (2014)

Forest plot for the association between ADRB2-16Arg/Gly and COPD risk among smoking Asians under allele and dominant genetic models. (A) dominant model, (B) allele model, fixed-effects model was used
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401053&req=5

Figure 3: Forest plot for the association between ADRB2-16Arg/Gly and COPD risk among smoking Asians under allele and dominant genetic models. (A) dominant model, (B) allele model, fixed-effects model was used
Mentions: In smoking Asian subgroup, the variant genotypes (Gly/Gly and Arg/Gly) had significant relationship with COPD risk compared with the wild type Arg/Arg homozygote (Gly/Gly vs. Arg/Arg: OR = 0.64, 95% CI = 0.41–0.99, P = 0.153 for heterogeneity, z = 2.01, P = 0.044 for OR; Arg/Gly vs. Arg/Arg: OR = 0.70, 95% CI = 0.50–0.99, P = 0.607 for heterogeneity, z = 1.99, P = 0.046 for OR). Similar results were identified among smoking Asians under the dominant model and allele model (dominant model: OR = 1.45, 95% CI = 1.04–2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03–1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR) (Fig. 3A and B). No statistical association was observed in smoking European descendent subgroup. The stratification analysis by smoking status did not indicate any significant associations, except among undefined smoking populations for recessive model (OR = 0.45, 95% CI = 0.24–0.85, P = 0.389 for heterogeneity, z = 1.28, P = 0.201 for OR). In other subgroups by high-quality score (≥10), ethnicity, study sample size, source of controls and genotyping methods, the OR for each subgroup was not statistically significant. Results have been summarized in Table 3.

Bottom Line: However, the results were inconclusive.Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.More studies with larger sample sizes are needed to validate the results.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Respiratory Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei 430071, China.

ABSTRACT

Background: The association between β2-adrenergic receptor (ADRB2) -16Arg/Gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (COPD) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship.

Methods: The PubMed, EMBASE, ISI web of science, the Cochrane Database of Systematic Reviews, and Chinese databases (CNKI, Wanfang Data, CBM, VIP) were searched for published literature. Odds ratios (OR) with 95% confidence interval (CI) were used to assess the strength of association.

Results: Eleven studies, comprising 1,128 COPD patients and 1,182 controls, were included in the meta-analysis. Overall, there was no significant association between the ADRB2-16Arg/Gly polymorphism and COPD risk in general population. In the stratification analysis by potential confounding variables, significant associations were observed between the ADRB2-16Arg/Gly polymorphism and COPD risk among smoking Asians under the dominant genetic model and allele model (Arg vs. Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.

Conclusion: This meta-analysis suggested that the ADRB2-16Arg/Gly polymorphism might be a potential risk factor for the development of COPD in smoking Asian populations, but not in European descendents, and tobacco smoking probably increased the genetic susceptibility. More studies with larger sample sizes are needed to validate the results.

No MeSH data available.


Related in: MedlinePlus