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Type 2 diabetes mellitus and risk of malignant melanoma: a systematic review and meta-analysis of cohort studies.

Qi L, Qi X, Xiong H, Liu Q, Li J, Zhang Y, Ma X, Wu N, Liu Q, Feng L - Iran. J. Public Health (2014)

Bottom Line: The pooled relative risks with the corresponding 95% confidence intervals (95% CIs) were calculated by using random-effects or random-effects model.For the population-based studies in which case cohort established, the relative risk was 1.85 (95% CI, 1.31-2.62).Further studies are needed to specifically test the effect, and fully elucidate the underlying pathophysiologic mechanisms.

View Article: PubMed Central - PubMed

Affiliation: 1. Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China ; 2. Dept. of Military Epidemiology, Third Military Medical University, Chongqing, China.

ABSTRACT

Background: Epidemiology studies have demonstrated inconsistent associations between type 2 diabetes mellitus and the risk of malignant melanoma. To this end, the aim was to perform a meta-analysis of cohort studies.

Method: Medline, PubMed, Embase and the Cochrane Library were searched up to February 2014. Cohort studies addressing the relative risk of type 2 diabetes mellitus on malignant melanoma were included in this meta-analysis. The Newcastle-Ottawa Scale was applied for quality evaluation. The pooled relative risks with the corresponding 95% confidence intervals (95% CIs) were calculated by using random-effects or random-effects model. Heterogeneity and publication bias were evaluated by I (2) and funnel plot analysis, respectively. Data was analyzed using STATA 11.0.

Results: A total of 9 independent cohorts from 8 manuscripts were entered this meta-analysis. Type 2 diabetes mellitus was slightly associated with an increased risk of malignant melanoma, and the pooled relative risk was 1.15 (95% CI, 1.00-1.32) in diabetes compared with non-diabetes with significant evidence of heterogeneity among these studies (P=0.016, I (2) =57.6%). For the studies adjusted for age, gender and obesity, the relative risks were 1.21 (95% CI, 1.03-1.42), 1.17 (95% CI, 1.01-1.35) and 1.11 (95% CI, 1.00-1.24), respectively. For the population-based studies in which case cohort established, the relative risk was 1.85 (95% CI, 1.31-2.62).

Conclusion: Type 2 diabetes might be an independent risk factor for malignant melanoma. Further studies are needed to specifically test the effect, and fully elucidate the underlying pathophysiologic mechanisms.

No MeSH data available.


Related in: MedlinePlus

Flow chart of the literature search strategy to identify cohort studies on melanoma and T2DM
© Copyright Policy - open-access
Related In: Results  -  Collection


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Figure 1: Flow chart of the literature search strategy to identify cohort studies on melanoma and T2DM

Mentions: The publication search process is shown in Fig. 1. First, a total of 2052 potentially relevant publications up to February 2014 were systematically identified through the previously listed databases. Of them, 1727 articles were excluded because they either did not meet the inclusion criteria or failed to provide adequate information to determine whether the criteria were satisfied in the first round screening after reading titles or abstracts. Among the remaining 325 studies, 306 articles were excluded because they did not contain data about melanoma or skin cancer. The remaining 19 articles were subjected to full-text reviews. And then, 11 articles were excluded because they were case reports, cross-sectional survey, case-control study, or only provided relationship of type 1 diabetes and melanoma, other type of skin cancer, or SMR of diabetes and melanoma. Finally, 9 cohort studies from 8 literatures (29-36) were eligible and included in the meta-analysis.


Type 2 diabetes mellitus and risk of malignant melanoma: a systematic review and meta-analysis of cohort studies.

Qi L, Qi X, Xiong H, Liu Q, Li J, Zhang Y, Ma X, Wu N, Liu Q, Feng L - Iran. J. Public Health (2014)

Flow chart of the literature search strategy to identify cohort studies on melanoma and T2DM
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401051&req=5

Figure 1: Flow chart of the literature search strategy to identify cohort studies on melanoma and T2DM
Mentions: The publication search process is shown in Fig. 1. First, a total of 2052 potentially relevant publications up to February 2014 were systematically identified through the previously listed databases. Of them, 1727 articles were excluded because they either did not meet the inclusion criteria or failed to provide adequate information to determine whether the criteria were satisfied in the first round screening after reading titles or abstracts. Among the remaining 325 studies, 306 articles were excluded because they did not contain data about melanoma or skin cancer. The remaining 19 articles were subjected to full-text reviews. And then, 11 articles were excluded because they were case reports, cross-sectional survey, case-control study, or only provided relationship of type 1 diabetes and melanoma, other type of skin cancer, or SMR of diabetes and melanoma. Finally, 9 cohort studies from 8 literatures (29-36) were eligible and included in the meta-analysis.

Bottom Line: The pooled relative risks with the corresponding 95% confidence intervals (95% CIs) were calculated by using random-effects or random-effects model.For the population-based studies in which case cohort established, the relative risk was 1.85 (95% CI, 1.31-2.62).Further studies are needed to specifically test the effect, and fully elucidate the underlying pathophysiologic mechanisms.

View Article: PubMed Central - PubMed

Affiliation: 1. Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China ; 2. Dept. of Military Epidemiology, Third Military Medical University, Chongqing, China.

ABSTRACT

Background: Epidemiology studies have demonstrated inconsistent associations between type 2 diabetes mellitus and the risk of malignant melanoma. To this end, the aim was to perform a meta-analysis of cohort studies.

Method: Medline, PubMed, Embase and the Cochrane Library were searched up to February 2014. Cohort studies addressing the relative risk of type 2 diabetes mellitus on malignant melanoma were included in this meta-analysis. The Newcastle-Ottawa Scale was applied for quality evaluation. The pooled relative risks with the corresponding 95% confidence intervals (95% CIs) were calculated by using random-effects or random-effects model. Heterogeneity and publication bias were evaluated by I (2) and funnel plot analysis, respectively. Data was analyzed using STATA 11.0.

Results: A total of 9 independent cohorts from 8 manuscripts were entered this meta-analysis. Type 2 diabetes mellitus was slightly associated with an increased risk of malignant melanoma, and the pooled relative risk was 1.15 (95% CI, 1.00-1.32) in diabetes compared with non-diabetes with significant evidence of heterogeneity among these studies (P=0.016, I (2) =57.6%). For the studies adjusted for age, gender and obesity, the relative risks were 1.21 (95% CI, 1.03-1.42), 1.17 (95% CI, 1.01-1.35) and 1.11 (95% CI, 1.00-1.24), respectively. For the population-based studies in which case cohort established, the relative risk was 1.85 (95% CI, 1.31-2.62).

Conclusion: Type 2 diabetes might be an independent risk factor for malignant melanoma. Further studies are needed to specifically test the effect, and fully elucidate the underlying pathophysiologic mechanisms.

No MeSH data available.


Related in: MedlinePlus