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Neural organization of spoken language revealed by lesion-symptom mapping.

Mirman D, Chen Q, Zhang Y, Wang Z, Faseyitan OK, Coslett HB, Schwartz MF - Nat Commun (2015)

Bottom Line: In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language.Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively.These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

View Article: PubMed Central - PubMed

Affiliation: 1] Moss Rehabilitation Research Institute, 50 Township Line Road, Elkins Park, Pennsylvania 19027, USA [2] Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA.

ABSTRACT
Studies of patients with acquired cognitive deficits following brain damage and studies using contemporary neuroimaging techniques form two distinct streams of research on the neural basis of cognition. In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language. Our results reveal two major divisions within the language system-meaning versus form and recognition versus production-and their instantiation in the brain. Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively. These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

No MeSH data available.


Related in: MedlinePlus

VLSM of Speech Recognition and ProductionVLSM t-map showing supra-threshold (FDR q = 0.05) voxels for the Speech Production factor (blue-green) and the Speech Recognition factor (red-yellow) with direct total lesion volume control.
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Figure 4: VLSM of Speech Recognition and ProductionVLSM t-map showing supra-threshold (FDR q = 0.05) voxels for the Speech Production factor (blue-green) and the Speech Recognition factor (red-yellow) with direct total lesion volume control.

Mentions: VLSM of the Speech Production factor identified a region superior to the Sylvian fissure, primarily in the supramarginal gyrus and extending anteriorly into inferior postcentral, precentral, and premotor cortex (Fig. 4, blue-green). These regions form part of the dorsal language pathway of dual-pathway models and have been shown in other reports to be involved in speech production6,31,32. VLSM of the Speech Recognition factor identified a parallel region inferior to the Sylvian fissure, primarily in the superior temporal gyrus, including prominent involvement in Wernicke’s area and extending deep into planum temporale (Fig. 4, red-yellow). Together, these two factors map the classic peri-Sylvian language regions; and the superior-inferior division between production and recognition provides new evidence to refine the dorsal-ventral division in dual-pathway models of speech processing6,8.


Neural organization of spoken language revealed by lesion-symptom mapping.

Mirman D, Chen Q, Zhang Y, Wang Z, Faseyitan OK, Coslett HB, Schwartz MF - Nat Commun (2015)

VLSM of Speech Recognition and ProductionVLSM t-map showing supra-threshold (FDR q = 0.05) voxels for the Speech Production factor (blue-green) and the Speech Recognition factor (red-yellow) with direct total lesion volume control.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400840&req=5

Figure 4: VLSM of Speech Recognition and ProductionVLSM t-map showing supra-threshold (FDR q = 0.05) voxels for the Speech Production factor (blue-green) and the Speech Recognition factor (red-yellow) with direct total lesion volume control.
Mentions: VLSM of the Speech Production factor identified a region superior to the Sylvian fissure, primarily in the supramarginal gyrus and extending anteriorly into inferior postcentral, precentral, and premotor cortex (Fig. 4, blue-green). These regions form part of the dorsal language pathway of dual-pathway models and have been shown in other reports to be involved in speech production6,31,32. VLSM of the Speech Recognition factor identified a parallel region inferior to the Sylvian fissure, primarily in the superior temporal gyrus, including prominent involvement in Wernicke’s area and extending deep into planum temporale (Fig. 4, red-yellow). Together, these two factors map the classic peri-Sylvian language regions; and the superior-inferior division between production and recognition provides new evidence to refine the dorsal-ventral division in dual-pathway models of speech processing6,8.

Bottom Line: In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language.Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively.These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

View Article: PubMed Central - PubMed

Affiliation: 1] Moss Rehabilitation Research Institute, 50 Township Line Road, Elkins Park, Pennsylvania 19027, USA [2] Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA.

ABSTRACT
Studies of patients with acquired cognitive deficits following brain damage and studies using contemporary neuroimaging techniques form two distinct streams of research on the neural basis of cognition. In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language. Our results reveal two major divisions within the language system-meaning versus form and recognition versus production-and their instantiation in the brain. Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively. These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

No MeSH data available.


Related in: MedlinePlus