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Neural organization of spoken language revealed by lesion-symptom mapping.

Mirman D, Chen Q, Zhang Y, Wang Z, Faseyitan OK, Coslett HB, Schwartz MF - Nat Commun (2015)

Bottom Line: In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language.Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively.These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

View Article: PubMed Central - PubMed

Affiliation: 1] Moss Rehabilitation Research Institute, 50 Township Line Road, Elkins Park, Pennsylvania 19027, USA [2] Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA.

ABSTRACT
Studies of patients with acquired cognitive deficits following brain damage and studies using contemporary neuroimaging techniques form two distinct streams of research on the neural basis of cognition. In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language. Our results reveal two major divisions within the language system-meaning versus form and recognition versus production-and their instantiation in the brain. Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively. These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

No MeSH data available.


Related in: MedlinePlus

VLSM of Semantic ErrorsVLSM t-map supra-threshold (FDR q = 0.05, t < −2.66) voxels for Semantic Errors factor scores with direct total lesion volume control.
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Figure 2: VLSM of Semantic ErrorsVLSM t-map supra-threshold (FDR q = 0.05, t < −2.66) voxels for Semantic Errors factor scores with direct total lesion volume control.

Mentions: VLSM of the Semantic Errors factor (Fig. 2) reproduced (with a larger sample of participants and transformed behavioral measure) our group’s previous findings that focal lesions of the left anterior temporal lobe (ATL) are associated with increased semantic errors in picture naming17,18 (and a similar pattern is observed in progressive aphasia due to neurodegenerative disease19,20). The behavioral dissociation of the Semantic Errors factor from the Semantic Recognition factor further indicates that the left ATL is specifically involved in semantically-driven spoken word production. This result also shows that there was sufficient statistical power to detect lesion-symptom associations in the left ATL. Theories that emphasize the role of the ATL in modality independent semantic processing10,19–23 would predict this as the most likely location where lesions would cause deficits in Semantic Recognition.


Neural organization of spoken language revealed by lesion-symptom mapping.

Mirman D, Chen Q, Zhang Y, Wang Z, Faseyitan OK, Coslett HB, Schwartz MF - Nat Commun (2015)

VLSM of Semantic ErrorsVLSM t-map supra-threshold (FDR q = 0.05, t < −2.66) voxels for Semantic Errors factor scores with direct total lesion volume control.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400840&req=5

Figure 2: VLSM of Semantic ErrorsVLSM t-map supra-threshold (FDR q = 0.05, t < −2.66) voxels for Semantic Errors factor scores with direct total lesion volume control.
Mentions: VLSM of the Semantic Errors factor (Fig. 2) reproduced (with a larger sample of participants and transformed behavioral measure) our group’s previous findings that focal lesions of the left anterior temporal lobe (ATL) are associated with increased semantic errors in picture naming17,18 (and a similar pattern is observed in progressive aphasia due to neurodegenerative disease19,20). The behavioral dissociation of the Semantic Errors factor from the Semantic Recognition factor further indicates that the left ATL is specifically involved in semantically-driven spoken word production. This result also shows that there was sufficient statistical power to detect lesion-symptom associations in the left ATL. Theories that emphasize the role of the ATL in modality independent semantic processing10,19–23 would predict this as the most likely location where lesions would cause deficits in Semantic Recognition.

Bottom Line: In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language.Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively.These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

View Article: PubMed Central - PubMed

Affiliation: 1] Moss Rehabilitation Research Institute, 50 Township Line Road, Elkins Park, Pennsylvania 19027, USA [2] Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA.

ABSTRACT
Studies of patients with acquired cognitive deficits following brain damage and studies using contemporary neuroimaging techniques form two distinct streams of research on the neural basis of cognition. In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language. Our results reveal two major divisions within the language system-meaning versus form and recognition versus production-and their instantiation in the brain. Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively. These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

No MeSH data available.


Related in: MedlinePlus