Limits...
Evaluation of different aspects of power Doppler sonography in differentiating and prognostication of breast masses.

Sirous M, Sirous R, Nejad FK, Rabeie E, Mansouri M - J Res Med Sci (2015)

Bottom Line: We compared our radiologic findings concerning different histopathologic and hormonal aspects of the lesions.A PI value higher than 1.6 has a sensitivity and specificity value of 70% and 98%, respectively, as a malignancy sign (P = 0.02 and 0.04, respectively).It seems that while malignant tumors have significantly higher number of vessels in comparison to benign one, since the number of vessels overlap between benign and malignant tumors, this aspect has little clinical usefulness in distinguishing or prognostication of breast masses.

View Article: PubMed Central - PubMed

Affiliation: Isfahan University of Medical Sciences, Department of Radiology, Isfahan, Iran.

ABSTRACT

Background: We conducted our study on 1110 patients with breast masses in order to investigate different aspects of power Doppler sonography (PDS) for differentiating between benign and malignant breast lesions and their prognostication.

Materials and methods: This study was conducted on the women who were referred to the sonography units of University Hospitals for breast sonography and had a BIRADS-3 mass or higher in gray scale sonography. Then, PDS was performed for all the patients. Vascularization, number of vessels, resistance index (RI), pulsatility index (PI), and vascularization patterns were evaluated for all the lesions. We compared our radiologic findings concerning different histopathologic and hormonal aspects of the lesions.

Results: The differences between mean vascular density in malignant lesions concerning size of the tumor, histological grade, stage, and hormone receptor status were statistically significant. Although, there was an overlap between benign and malignant values. A resistive index (RI) value higher than 0.83 as a sign for malignancy had sensitivity equal to 75% and specificity equal to 97% (P = 0.04 and 0.03, respectively). A PI value higher than 1.6 has a sensitivity and specificity value of 70% and 98%, respectively, as a malignancy sign (P = 0.02 and 0.04, respectively).

Conclusion: It seems that while malignant tumors have significantly higher number of vessels in comparison to benign one, since the number of vessels overlap between benign and malignant tumors, this aspect has little clinical usefulness in distinguishing or prognostication of breast masses. In contrast RI, PI, and vascularization pattern have an ability to differentiate and predict the prognosis of breast lesions.

No MeSH data available.


Related in: MedlinePlus

View of a malignant lesion in color Doppler sonography with penetration of vessels
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4400706&req=5

Figure 3: View of a malignant lesion in color Doppler sonography with penetration of vessels

Mentions: To evaluate the potential of PDS in differentiating between malignant and benign breast lesions, we studied different parameters. First, we studied the mean vascular density (number of vessels per cm2 of lesion). According to our results, mean vascular density was significantly higher in malignant versus benign breast masses. Since other studies have suggested that the tumors’ size may be associated with a higher detection of vessels in malignant lesions,[10151630] logistic regression was performed to control the effect of the tumor size. It was revealed that higher detection rates of vessels on breast cancers are correlated with the malignant nature of the tumor itself. However, the values of malignant and benign lesions overlap significantly [Figures 1–3]. Hence, like many other studies, it was confirmed in our study that the number of vessels has little clinical usefulness in distinguishing between benign and malignant tumors.[17181923]


Evaluation of different aspects of power Doppler sonography in differentiating and prognostication of breast masses.

Sirous M, Sirous R, Nejad FK, Rabeie E, Mansouri M - J Res Med Sci (2015)

View of a malignant lesion in color Doppler sonography with penetration of vessels
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400706&req=5

Figure 3: View of a malignant lesion in color Doppler sonography with penetration of vessels
Mentions: To evaluate the potential of PDS in differentiating between malignant and benign breast lesions, we studied different parameters. First, we studied the mean vascular density (number of vessels per cm2 of lesion). According to our results, mean vascular density was significantly higher in malignant versus benign breast masses. Since other studies have suggested that the tumors’ size may be associated with a higher detection of vessels in malignant lesions,[10151630] logistic regression was performed to control the effect of the tumor size. It was revealed that higher detection rates of vessels on breast cancers are correlated with the malignant nature of the tumor itself. However, the values of malignant and benign lesions overlap significantly [Figures 1–3]. Hence, like many other studies, it was confirmed in our study that the number of vessels has little clinical usefulness in distinguishing between benign and malignant tumors.[17181923]

Bottom Line: We compared our radiologic findings concerning different histopathologic and hormonal aspects of the lesions.A PI value higher than 1.6 has a sensitivity and specificity value of 70% and 98%, respectively, as a malignancy sign (P = 0.02 and 0.04, respectively).It seems that while malignant tumors have significantly higher number of vessels in comparison to benign one, since the number of vessels overlap between benign and malignant tumors, this aspect has little clinical usefulness in distinguishing or prognostication of breast masses.

View Article: PubMed Central - PubMed

Affiliation: Isfahan University of Medical Sciences, Department of Radiology, Isfahan, Iran.

ABSTRACT

Background: We conducted our study on 1110 patients with breast masses in order to investigate different aspects of power Doppler sonography (PDS) for differentiating between benign and malignant breast lesions and their prognostication.

Materials and methods: This study was conducted on the women who were referred to the sonography units of University Hospitals for breast sonography and had a BIRADS-3 mass or higher in gray scale sonography. Then, PDS was performed for all the patients. Vascularization, number of vessels, resistance index (RI), pulsatility index (PI), and vascularization patterns were evaluated for all the lesions. We compared our radiologic findings concerning different histopathologic and hormonal aspects of the lesions.

Results: The differences between mean vascular density in malignant lesions concerning size of the tumor, histological grade, stage, and hormone receptor status were statistically significant. Although, there was an overlap between benign and malignant values. A resistive index (RI) value higher than 0.83 as a sign for malignancy had sensitivity equal to 75% and specificity equal to 97% (P = 0.04 and 0.03, respectively). A PI value higher than 1.6 has a sensitivity and specificity value of 70% and 98%, respectively, as a malignancy sign (P = 0.02 and 0.04, respectively).

Conclusion: It seems that while malignant tumors have significantly higher number of vessels in comparison to benign one, since the number of vessels overlap between benign and malignant tumors, this aspect has little clinical usefulness in distinguishing or prognostication of breast masses. In contrast RI, PI, and vascularization pattern have an ability to differentiate and predict the prognosis of breast lesions.

No MeSH data available.


Related in: MedlinePlus