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Adherence to statin therapy in patients with type 2 diabetes: An important dilemma.

Farsaei S, Sabzghabaee AM, Amini M, Zargarzadeh AH - J Res Med Sci (2015)

Bottom Line: Despite the importance of patients' adherence to their drug treatments for achieving desired therapeutic goals and the proven role 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) for the health status of patients with cardiovascular diseases, there is not enough information regarding diabetic patients' adherence to statin therapy in developing countries.Adherence rate was 79.7% and 69% according to pill counting and self-reporting among study population.Moreover, 68.4% of patients achieved their LDL cholesterol goal of <100 mg/dl and adherent patients reached therapeutic goal significantly more than those who were considered non-adherence to statin therapy (P < 0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Despite the importance of patients' adherence to their drug treatments for achieving desired therapeutic goals and the proven role 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) for the health status of patients with cardiovascular diseases, there is not enough information regarding diabetic patients' adherence to statin therapy in developing countries. In this clinical study we aimed to assess the adherence of diabetes type 2 patients to statin therapy in a research based community clinic in Iran.

Materials and methods: In this prospective clinical study which was done at Isfahan Endocrinology and Metabolism Research Center, 204 diabetic type 2 patients under treatment with statin were interviewed twice and their demographic data (age, gender, body mass index, education), statin information (type, dose) and their serum lipid profile were recorded. Three months after the initial visits, patients were assessed using pill counting method and according to patients' self-reporting and also assessed low-density lipoprotein (LDL) cholesterol goal attainment <100 mg/dl.

Results: Adherence rate was 79.7% and 69% according to pill counting and self-reporting among study population. Moreover, 68.4% of patients achieved their LDL cholesterol goal of <100 mg/dl and adherent patients reached therapeutic goal significantly more than those who were considered non-adherence to statin therapy (P < 0.01).

Conclusion: Adherence to statin therapy, as reflected by pill count method, is significantly related to LDL cholesterol goal achievement in patients with diabetes and dyslipidemia. Pill count method can be used to identify patients who are nonadherent to statin therapy and at high risk for failure to attain LDL cholesterol goals.

No MeSH data available.


Related in: MedlinePlus

Follow-up chart of the studied patients
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Figure 1: Follow-up chart of the studied patients

Mentions: Among 204 patients met inclusion criteria, 46 patients were excluded during the study and final analyses were conducted with the data from 158 patients who completed the study [Figure 1]. Lovastatin was prescribed for more than 98% of patients in our study with dose of 10.2 ± 3.7 mg daily and <2% of patients received atorvastatin or simvastatin as cholesterol lowering agent. Therefore the analysis was not conducted based on type of statins.


Adherence to statin therapy in patients with type 2 diabetes: An important dilemma.

Farsaei S, Sabzghabaee AM, Amini M, Zargarzadeh AH - J Res Med Sci (2015)

Follow-up chart of the studied patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400702&req=5

Figure 1: Follow-up chart of the studied patients
Mentions: Among 204 patients met inclusion criteria, 46 patients were excluded during the study and final analyses were conducted with the data from 158 patients who completed the study [Figure 1]. Lovastatin was prescribed for more than 98% of patients in our study with dose of 10.2 ± 3.7 mg daily and <2% of patients received atorvastatin or simvastatin as cholesterol lowering agent. Therefore the analysis was not conducted based on type of statins.

Bottom Line: Despite the importance of patients' adherence to their drug treatments for achieving desired therapeutic goals and the proven role 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) for the health status of patients with cardiovascular diseases, there is not enough information regarding diabetic patients' adherence to statin therapy in developing countries.Adherence rate was 79.7% and 69% according to pill counting and self-reporting among study population.Moreover, 68.4% of patients achieved their LDL cholesterol goal of <100 mg/dl and adherent patients reached therapeutic goal significantly more than those who were considered non-adherence to statin therapy (P < 0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Despite the importance of patients' adherence to their drug treatments for achieving desired therapeutic goals and the proven role 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) for the health status of patients with cardiovascular diseases, there is not enough information regarding diabetic patients' adherence to statin therapy in developing countries. In this clinical study we aimed to assess the adherence of diabetes type 2 patients to statin therapy in a research based community clinic in Iran.

Materials and methods: In this prospective clinical study which was done at Isfahan Endocrinology and Metabolism Research Center, 204 diabetic type 2 patients under treatment with statin were interviewed twice and their demographic data (age, gender, body mass index, education), statin information (type, dose) and their serum lipid profile were recorded. Three months after the initial visits, patients were assessed using pill counting method and according to patients' self-reporting and also assessed low-density lipoprotein (LDL) cholesterol goal attainment <100 mg/dl.

Results: Adherence rate was 79.7% and 69% according to pill counting and self-reporting among study population. Moreover, 68.4% of patients achieved their LDL cholesterol goal of <100 mg/dl and adherent patients reached therapeutic goal significantly more than those who were considered non-adherence to statin therapy (P < 0.01).

Conclusion: Adherence to statin therapy, as reflected by pill count method, is significantly related to LDL cholesterol goal achievement in patients with diabetes and dyslipidemia. Pill count method can be used to identify patients who are nonadherent to statin therapy and at high risk for failure to attain LDL cholesterol goals.

No MeSH data available.


Related in: MedlinePlus