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The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling.

Lindström NO, Carragher NO, Hohenstein P - Stem Cell Reports (2015)

Bottom Line: Nephron progenitor cells differentiate to form nephrons during embryonic kidney development.In contrast, self-renewal maintains progenitor numbers and premature depletion leads to impaired kidney function.Here we analyze the PI3K pathway as a point of convergence for the multiple pathways that are known to control self-renewal in the kidney.

View Article: PubMed Central - PubMed

Affiliation: The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK; Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK. Electronic address: nils.lindstrom@roslin.ed.ac.uk.

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The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling.

Lindström NO, Carragher NO, Hohenstein P - Stem Cell Reports (2015)

© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400645&req=5

Bottom Line: Nephron progenitor cells differentiate to form nephrons during embryonic kidney development.In contrast, self-renewal maintains progenitor numbers and premature depletion leads to impaired kidney function.Here we analyze the PI3K pathway as a point of convergence for the multiple pathways that are known to control self-renewal in the kidney.

View Article: PubMed Central - PubMed

Affiliation: The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK; Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK. Electronic address: nils.lindstrom@roslin.ed.ac.uk.

Show MeSH
Related in: MedlinePlus