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The podocyte cytoskeleton in health and in disease.

Mathieson PW - Clin Kidney J (2012)

Bottom Line: Therapeutic agents that are beneficial in proteinuric disease may act at least partly by restoring the cell shape via effects on the actin cytoskeleton.Drugs that have beneficial effects on podocytes can improve our ability to treat important renal diseases including diabetic nephropathy.Currently available agents can be applied in this way and the rapid progress in the study of podocytes is highlighting new therapeutic targets that can bring even more specificity.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine & Dentistry , University of Bristol, North Bristol NHS Trust , Bristol , UK ; Academic Renal Unit , Southmead Hospital , Bristol , UK.

ABSTRACT
The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets. In particular, podocyte function is dependent on the cells' actin cytoskeleton: this maintains their complex structure. Alterations in the actin cytoskeleton arise from a variety of genetic and acquired causes. Therapeutic agents that are beneficial in proteinuric disease may act at least partly by restoring the cell shape via effects on the actin cytoskeleton. Recent studies of podocytes in vivo and in vitro are described, highlighting clinically relevant observations and those that help us understand the ways in which we may harness nature's own mechanisms to repair and/or renew these specialized glomerular cells, with a particular focus on their actin cytoskeleton. Drugs that have beneficial effects on podocytes can improve our ability to treat important renal diseases including diabetic nephropathy. Currently available agents can be applied in this way and the rapid progress in the study of podocytes is highlighting new therapeutic targets that can bring even more specificity.

No MeSH data available.


Related in: MedlinePlus

Scanning electron micrograph of podocytes on urinary aspect of normal glomerular capillary showing: (a) cell bodies, (b) primary processes and (c) interdigitating secondary processes that form filtration slits resembling the teeth of a zipper.
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SFS153F1: Scanning electron micrograph of podocytes on urinary aspect of normal glomerular capillary showing: (a) cell bodies, (b) primary processes and (c) interdigitating secondary processes that form filtration slits resembling the teeth of a zipper.

Mentions: Podocytes imaged by scanning electron microscopy are, in the opinion of this author, aesthetically very pleasing (Figure 1). They have a cell body, long primary processes and a complex network of interdigitating secondary processes. This complex cellular architecture is maintained by a precise organization of microtubules and actin filaments in the cellular cytoplasm.Fig. 1.


The podocyte cytoskeleton in health and in disease.

Mathieson PW - Clin Kidney J (2012)

Scanning electron micrograph of podocytes on urinary aspect of normal glomerular capillary showing: (a) cell bodies, (b) primary processes and (c) interdigitating secondary processes that form filtration slits resembling the teeth of a zipper.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400570&req=5

SFS153F1: Scanning electron micrograph of podocytes on urinary aspect of normal glomerular capillary showing: (a) cell bodies, (b) primary processes and (c) interdigitating secondary processes that form filtration slits resembling the teeth of a zipper.
Mentions: Podocytes imaged by scanning electron microscopy are, in the opinion of this author, aesthetically very pleasing (Figure 1). They have a cell body, long primary processes and a complex network of interdigitating secondary processes. This complex cellular architecture is maintained by a precise organization of microtubules and actin filaments in the cellular cytoplasm.Fig. 1.

Bottom Line: Therapeutic agents that are beneficial in proteinuric disease may act at least partly by restoring the cell shape via effects on the actin cytoskeleton.Drugs that have beneficial effects on podocytes can improve our ability to treat important renal diseases including diabetic nephropathy.Currently available agents can be applied in this way and the rapid progress in the study of podocytes is highlighting new therapeutic targets that can bring even more specificity.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine & Dentistry , University of Bristol, North Bristol NHS Trust , Bristol , UK ; Academic Renal Unit , Southmead Hospital , Bristol , UK.

ABSTRACT
The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets. In particular, podocyte function is dependent on the cells' actin cytoskeleton: this maintains their complex structure. Alterations in the actin cytoskeleton arise from a variety of genetic and acquired causes. Therapeutic agents that are beneficial in proteinuric disease may act at least partly by restoring the cell shape via effects on the actin cytoskeleton. Recent studies of podocytes in vivo and in vitro are described, highlighting clinically relevant observations and those that help us understand the ways in which we may harness nature's own mechanisms to repair and/or renew these specialized glomerular cells, with a particular focus on their actin cytoskeleton. Drugs that have beneficial effects on podocytes can improve our ability to treat important renal diseases including diabetic nephropathy. Currently available agents can be applied in this way and the rapid progress in the study of podocytes is highlighting new therapeutic targets that can bring even more specificity.

No MeSH data available.


Related in: MedlinePlus