Limits...
Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis.

Fatima H, Siew ED, Dwyer JP, Paueksakon P - Clin Kidney J (2012)

Bottom Line: We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria.Coexistent MG and PNCGN is a rare occurrence.We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Microbiology and Immunology (MCN C2318B) , Vanderbilt University Medical Center , Nashville, TN , USA.

ABSTRACT
We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria. Kidney biopsy showed membranous glomerulopathy (MG) with superimposed pauci-immune necrotizing crescentic glomerulonephritis (PNCGN). Coexistent MG and PNCGN is a rare occurrence. The diagnosis of such an exceptionally rare combination relies on the combination of renal biopsy findings and serologic testing. We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.

No MeSH data available.


Related in: MedlinePlus

Subepithelial immune complex deposits (arrow) with extensive foot process effacement (transmission electron microscopy, original magnification ×5600).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4400567&req=5

SFS145F4: Subepithelial immune complex deposits (arrow) with extensive foot process effacement (transmission electron microscopy, original magnification ×5600).

Mentions: On electron microscopy, GBM showed normal thickness of lamina densa with occasional to scattered small to medium subepithelial deposits (Figure 4), very rare small subendothelial deposits and rare mesangial deposits. There was ∼60% podocyte foot process effacement. There were no fibrin tactoids, tubuloreticular arrays and no increase in mesangial matrix or cellularity. There were no tubular basement membrane deposits.Fig. 4.


Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis.

Fatima H, Siew ED, Dwyer JP, Paueksakon P - Clin Kidney J (2012)

Subepithelial immune complex deposits (arrow) with extensive foot process effacement (transmission electron microscopy, original magnification ×5600).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400567&req=5

SFS145F4: Subepithelial immune complex deposits (arrow) with extensive foot process effacement (transmission electron microscopy, original magnification ×5600).
Mentions: On electron microscopy, GBM showed normal thickness of lamina densa with occasional to scattered small to medium subepithelial deposits (Figure 4), very rare small subendothelial deposits and rare mesangial deposits. There was ∼60% podocyte foot process effacement. There were no fibrin tactoids, tubuloreticular arrays and no increase in mesangial matrix or cellularity. There were no tubular basement membrane deposits.Fig. 4.

Bottom Line: We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria.Coexistent MG and PNCGN is a rare occurrence.We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Microbiology and Immunology (MCN C2318B) , Vanderbilt University Medical Center , Nashville, TN , USA.

ABSTRACT
We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria. Kidney biopsy showed membranous glomerulopathy (MG) with superimposed pauci-immune necrotizing crescentic glomerulonephritis (PNCGN). Coexistent MG and PNCGN is a rare occurrence. The diagnosis of such an exceptionally rare combination relies on the combination of renal biopsy findings and serologic testing. We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.

No MeSH data available.


Related in: MedlinePlus