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Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis.

Fatima H, Siew ED, Dwyer JP, Paueksakon P - Clin Kidney J (2012)

Bottom Line: We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria.Coexistent MG and PNCGN is a rare occurrence.We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Microbiology and Immunology (MCN C2318B) , Vanderbilt University Medical Center , Nashville, TN , USA.

ABSTRACT
We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria. Kidney biopsy showed membranous glomerulopathy (MG) with superimposed pauci-immune necrotizing crescentic glomerulonephritis (PNCGN). Coexistent MG and PNCGN is a rare occurrence. The diagnosis of such an exceptionally rare combination relies on the combination of renal biopsy findings and serologic testing. We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.

No MeSH data available.


Related in: MedlinePlus

Segmental finely granular 1+ staining of glomerular capillary wall for IgG (anti-IgG immunofluorescence, original magnification ×400).
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SFS145F3: Segmental finely granular 1+ staining of glomerular capillary wall for IgG (anti-IgG immunofluorescence, original magnification ×400).

Mentions: Five glomeruli were present in frozen sections processed for immunofluorescence microscopy. There was 1+ (0 to 3+ scale) segmental granular capillary loop and mesangial staining for immunoglobulin G (IgG) (Figure 3) and 1+ C3 and equal 1+ kappa and lambda light chain staining in a similar pattern as IgG. There was no glomerular staining for IgA, IgM and C1q. There was no tubular basement membrane staining for any antisera. Immunofluorescence studies for subclasses of IgG, namely IgG1, IgG2, IgG3 and IgG4 were performed. There was dominant IgG4 segmental granular capillary loop and mesangial staining. IgG1, IgG2 and IgG3 were negative.Fig. 3.


Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis.

Fatima H, Siew ED, Dwyer JP, Paueksakon P - Clin Kidney J (2012)

Segmental finely granular 1+ staining of glomerular capillary wall for IgG (anti-IgG immunofluorescence, original magnification ×400).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400567&req=5

SFS145F3: Segmental finely granular 1+ staining of glomerular capillary wall for IgG (anti-IgG immunofluorescence, original magnification ×400).
Mentions: Five glomeruli were present in frozen sections processed for immunofluorescence microscopy. There was 1+ (0 to 3+ scale) segmental granular capillary loop and mesangial staining for immunoglobulin G (IgG) (Figure 3) and 1+ C3 and equal 1+ kappa and lambda light chain staining in a similar pattern as IgG. There was no glomerular staining for IgA, IgM and C1q. There was no tubular basement membrane staining for any antisera. Immunofluorescence studies for subclasses of IgG, namely IgG1, IgG2, IgG3 and IgG4 were performed. There was dominant IgG4 segmental granular capillary loop and mesangial staining. IgG1, IgG2 and IgG3 were negative.Fig. 3.

Bottom Line: We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria.Coexistent MG and PNCGN is a rare occurrence.We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Microbiology and Immunology (MCN C2318B) , Vanderbilt University Medical Center , Nashville, TN , USA.

ABSTRACT
We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria. Kidney biopsy showed membranous glomerulopathy (MG) with superimposed pauci-immune necrotizing crescentic glomerulonephritis (PNCGN). Coexistent MG and PNCGN is a rare occurrence. The diagnosis of such an exceptionally rare combination relies on the combination of renal biopsy findings and serologic testing. We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.

No MeSH data available.


Related in: MedlinePlus