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Aspergillus arthritis and organ transplantation.

Figuères ML, Cantarovich D, Tattevin P, Le Pogamp P, Polard JL, Stock N, Blancho G - Clin Kidney J (2012)

Bottom Line: Treatment with voriconazole along with hip replacement led to complete recovery.However, drug interaction between immunosuppressive and anti-fungal drugs was complicated by cellular acute graft rejection.Aspergillus fumigatus arthritis is an uncommon and serious infection that should be evoked especially in the case of resistance to anti-microbial antibiotics and/or an atypical clinical picture.

View Article: PubMed Central - PubMed

Affiliation: Institut of Transplantation - Urology - Nephrology (ITUN), Hôtel Dieu. CHU de Nantes, France.

ABSTRACT
We report a case of a kidney and pancreas transplanted patient, hospitalized for septic hip arthritis. The whole diagnostic work-up including synovial and bone biopsies remained negative. After inefficient empirical anti-bacterial antibiotic treatment, femoral head resection was performed and tissue analysis revealed Aspergillus fumigatus hyphae. Treatment with voriconazole along with hip replacement led to complete recovery. However, drug interaction between immunosuppressive and anti-fungal drugs was complicated by cellular acute graft rejection. Aspergillus fumigatus arthritis is an uncommon and serious infection that should be evoked especially in the case of resistance to anti-microbial antibiotics and/or an atypical clinical picture.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance imaging: severe left femoral head destruction from an acute inflammatory process.
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fig3: Magnetic resonance imaging: severe left femoral head destruction from an acute inflammatory process.

Mentions: Magnetic resonance imaging revealed severe joint degradation (Figure 3), and a femoral head resection was performed in December 2008, temporarily replaced by a spacer with a high-viscosity bone cement containing gentamycin. Surgical biopsies of bone and synovial tissue revealed branching septated hyphae on haematoxylin–eosin stain and all cultures grew A. fumigatus (Figure 4a and b).


Aspergillus arthritis and organ transplantation.

Figuères ML, Cantarovich D, Tattevin P, Le Pogamp P, Polard JL, Stock N, Blancho G - Clin Kidney J (2012)

Magnetic resonance imaging: severe left femoral head destruction from an acute inflammatory process.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400502&req=5

fig3: Magnetic resonance imaging: severe left femoral head destruction from an acute inflammatory process.
Mentions: Magnetic resonance imaging revealed severe joint degradation (Figure 3), and a femoral head resection was performed in December 2008, temporarily replaced by a spacer with a high-viscosity bone cement containing gentamycin. Surgical biopsies of bone and synovial tissue revealed branching septated hyphae on haematoxylin–eosin stain and all cultures grew A. fumigatus (Figure 4a and b).

Bottom Line: Treatment with voriconazole along with hip replacement led to complete recovery.However, drug interaction between immunosuppressive and anti-fungal drugs was complicated by cellular acute graft rejection.Aspergillus fumigatus arthritis is an uncommon and serious infection that should be evoked especially in the case of resistance to anti-microbial antibiotics and/or an atypical clinical picture.

View Article: PubMed Central - PubMed

Affiliation: Institut of Transplantation - Urology - Nephrology (ITUN), Hôtel Dieu. CHU de Nantes, France.

ABSTRACT
We report a case of a kidney and pancreas transplanted patient, hospitalized for septic hip arthritis. The whole diagnostic work-up including synovial and bone biopsies remained negative. After inefficient empirical anti-bacterial antibiotic treatment, femoral head resection was performed and tissue analysis revealed Aspergillus fumigatus hyphae. Treatment with voriconazole along with hip replacement led to complete recovery. However, drug interaction between immunosuppressive and anti-fungal drugs was complicated by cellular acute graft rejection. Aspergillus fumigatus arthritis is an uncommon and serious infection that should be evoked especially in the case of resistance to anti-microbial antibiotics and/or an atypical clinical picture.

No MeSH data available.


Related in: MedlinePlus