Limits...
Balkan endemic nephropathy-current status and future perspectives.

Pavlović NM - Clin Kidney J (2013)

Bottom Line: The clinical signs and symptoms of BEN are non-specific and often remain unrecognized for years.Although the aetiology has been extensively studied, fostering the publication of various hypotheses, only one of them has provided conclusive evidence related to the aetiology of BEN.Studies conducted over the past decade have provided particularly strong arguments that BEN and UUC are caused by chronic poisoning with aristolochic acids (AAs).

View Article: PubMed Central - PubMed

Affiliation: Clinic of Nephrology, Clinical Centre , Nis , Serbia.

ABSTRACT
Balkan endemic nephropathy (BEN), originally described in 1956, is a unique familial, chronic renal disease encountered with a high-prevalence rate in Serbia, Bulgaria, Romania, Croatia and Bosnia and Herzegovina. The most prominent features of the disease are its endemic nature, long-incubation period, familial clustering of the disease and an unusually high incidence of associated upper urothelial cancer (UUC). There are no clear-cut data on BEN incidence and prevalence, since the studies carried out in different endemic areas yielded contradictory information. In spite of intermittent variations, the incidence of new cases has remained stable over time. It has been estimated that almost 100 000 people are at risk of BEN, whereas 25 000 have the disease. The clinical signs and symptoms of BEN are non-specific and often remain unrecognized for years. There are no pathognomonic diagnostic features of BEN, but the set of epidemiological, clinical and biochemical data along with the pattern of pathologic injury in the absence of any other renal diseases are highly suggestive of this entity. Although the aetiology has been extensively studied, fostering the publication of various hypotheses, only one of them has provided conclusive evidence related to the aetiology of BEN. Studies conducted over the past decade have provided particularly strong arguments that BEN and UUC are caused by chronic poisoning with aristolochic acids (AAs). In light of these later studies, one can raise the question whether AAs could be responsible for previously and currently widespread unrecognized global renal disease and UUC.

No MeSH data available.


Related in: MedlinePlus

Post harvests second generation Aristolochia Clematitis growing in the wheat field (A), with ripe seeds in the soil (B) and wheat grain from that field (C) (hyperendemic village Petka, Serbia, 2011).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4400492&req=5

SFT049F3: Post harvests second generation Aristolochia Clematitis growing in the wheat field (A), with ripe seeds in the soil (B) and wheat grain from that field (C) (hyperendemic village Petka, Serbia, 2011).

Mentions: Aristolochia clematitis is one of the old healing plants already in use by the ancient Egyptians and Greeks (Figure 3). The Greek name ‘Aristolochia’ is a compound word made up of áristos—fair, beautiful, and lochia—menstrual periods. It refers to the use of the plant in aiding childbirth and was prescribed by the Greeks to women following delivery to facilitate a resuming of their periods. The species name, ‘Clematitis' derives from the Greek 'klema' for tendril, the growth form of this species of Aristolochia. The English name 'birthwort' likewise refers to the plant's use as an aid to birth [31]. Although herbal drugs derived from Aristolochia spp. have been known since antiquity and were used in obstetrics and in the treatment of snake bites (Rosenmund and Reichstein, 1943) [32] in 1981, the use of Aristolochia spp. was forbidden in many countries due to possible carcinogenic effects. Peters and Hedwall in 1962 indicated that AA was known to be nephrotoxic in the rabbit as early as in 1892, in the horse in 1893 and in the rabbit and the mouse in 1958 [33].Fig. 3.


Balkan endemic nephropathy-current status and future perspectives.

Pavlović NM - Clin Kidney J (2013)

Post harvests second generation Aristolochia Clematitis growing in the wheat field (A), with ripe seeds in the soil (B) and wheat grain from that field (C) (hyperendemic village Petka, Serbia, 2011).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400492&req=5

SFT049F3: Post harvests second generation Aristolochia Clematitis growing in the wheat field (A), with ripe seeds in the soil (B) and wheat grain from that field (C) (hyperendemic village Petka, Serbia, 2011).
Mentions: Aristolochia clematitis is one of the old healing plants already in use by the ancient Egyptians and Greeks (Figure 3). The Greek name ‘Aristolochia’ is a compound word made up of áristos—fair, beautiful, and lochia—menstrual periods. It refers to the use of the plant in aiding childbirth and was prescribed by the Greeks to women following delivery to facilitate a resuming of their periods. The species name, ‘Clematitis' derives from the Greek 'klema' for tendril, the growth form of this species of Aristolochia. The English name 'birthwort' likewise refers to the plant's use as an aid to birth [31]. Although herbal drugs derived from Aristolochia spp. have been known since antiquity and were used in obstetrics and in the treatment of snake bites (Rosenmund and Reichstein, 1943) [32] in 1981, the use of Aristolochia spp. was forbidden in many countries due to possible carcinogenic effects. Peters and Hedwall in 1962 indicated that AA was known to be nephrotoxic in the rabbit as early as in 1892, in the horse in 1893 and in the rabbit and the mouse in 1958 [33].Fig. 3.

Bottom Line: The clinical signs and symptoms of BEN are non-specific and often remain unrecognized for years.Although the aetiology has been extensively studied, fostering the publication of various hypotheses, only one of them has provided conclusive evidence related to the aetiology of BEN.Studies conducted over the past decade have provided particularly strong arguments that BEN and UUC are caused by chronic poisoning with aristolochic acids (AAs).

View Article: PubMed Central - PubMed

Affiliation: Clinic of Nephrology, Clinical Centre , Nis , Serbia.

ABSTRACT
Balkan endemic nephropathy (BEN), originally described in 1956, is a unique familial, chronic renal disease encountered with a high-prevalence rate in Serbia, Bulgaria, Romania, Croatia and Bosnia and Herzegovina. The most prominent features of the disease are its endemic nature, long-incubation period, familial clustering of the disease and an unusually high incidence of associated upper urothelial cancer (UUC). There are no clear-cut data on BEN incidence and prevalence, since the studies carried out in different endemic areas yielded contradictory information. In spite of intermittent variations, the incidence of new cases has remained stable over time. It has been estimated that almost 100 000 people are at risk of BEN, whereas 25 000 have the disease. The clinical signs and symptoms of BEN are non-specific and often remain unrecognized for years. There are no pathognomonic diagnostic features of BEN, but the set of epidemiological, clinical and biochemical data along with the pattern of pathologic injury in the absence of any other renal diseases are highly suggestive of this entity. Although the aetiology has been extensively studied, fostering the publication of various hypotheses, only one of them has provided conclusive evidence related to the aetiology of BEN. Studies conducted over the past decade have provided particularly strong arguments that BEN and UUC are caused by chronic poisoning with aristolochic acids (AAs). In light of these later studies, one can raise the question whether AAs could be responsible for previously and currently widespread unrecognized global renal disease and UUC.

No MeSH data available.


Related in: MedlinePlus