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Possible potassium chlorate nephrotoxicity associated with chronic matchstick ingestion.

Thurlow JS, Little DJ, Baker TP, Yuan CM - Clin Kidney J (2013)

Bottom Line: He reported regular matchstick consumption to prevent chigger (Trombicula autumnalis) bites, amounting to ∼5.8 g of potassium chlorate over 3 years.Potassium chlorate can cause anuric renal failure within days of a toxic dose.This case represents possible sequelae of chronic potassium chlorate ingestion.

View Article: PubMed Central - PubMed

Affiliation: Nephrology Service, Department of Medicine , Walter Reed National Military Medical Center , Bethesda, MD , USA.

ABSTRACT
We present a case of a 48-year-old active duty male soldier with a history of chronic exposure to potassium chlorate, later diagnosed with chronic interstitial nephritis. He reported regular matchstick consumption to prevent chigger (Trombicula autumnalis) bites, amounting to ∼5.8 g of potassium chlorate over 3 years. Potassium chlorate can cause anuric renal failure within days of a toxic dose. Its slow excretion and mechanism of action suggest that renal toxicity may result from lower-dose chronic exposure. This case represents possible sequelae of chronic potassium chlorate ingestion.

No MeSH data available.


Related in: MedlinePlus

Renal biopsy. Focal interstitial fibrosis with associated tubular atrophy is seen surrounded by otherwise unremarkable tubulointerstitium. Masson Trichome stain 20× field.
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SFT034F1: Renal biopsy. Focal interstitial fibrosis with associated tubular atrophy is seen surrounded by otherwise unremarkable tubulointerstitium. Masson Trichome stain 20× field.

Mentions: An adequate diagnostic renal biopsy (Figure 1) demonstrated 5–10% interstitial fibrosis and tubular atrophy most consistent with chronic tubulointerstitial disease; 7–10% of glomeruli were sclerosed and obsolescent. There was no evidence of glomerulopathy, vasculitis or arteriosclerosis, and no active interstitial inflammation. Viable glomeruli were normocellular with open capillary loops and no increased mesangial matrix. No deposits were evident on Masson Trichrome stain. Ultrastructural evaluation demonstrated a normal glomerular capillary basement membrane thickness and no deposits. Immunofluorescence demonstrated low-intensity focal and granular deposition of IgM and C3 in the mesangia of all visualized glomeruli. Staining was negative for Kappa and Lambda light chains, IgG, IgA, albumin and C1q.Fig. 1.


Possible potassium chlorate nephrotoxicity associated with chronic matchstick ingestion.

Thurlow JS, Little DJ, Baker TP, Yuan CM - Clin Kidney J (2013)

Renal biopsy. Focal interstitial fibrosis with associated tubular atrophy is seen surrounded by otherwise unremarkable tubulointerstitium. Masson Trichome stain 20× field.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4400479&req=5

SFT034F1: Renal biopsy. Focal interstitial fibrosis with associated tubular atrophy is seen surrounded by otherwise unremarkable tubulointerstitium. Masson Trichome stain 20× field.
Mentions: An adequate diagnostic renal biopsy (Figure 1) demonstrated 5–10% interstitial fibrosis and tubular atrophy most consistent with chronic tubulointerstitial disease; 7–10% of glomeruli were sclerosed and obsolescent. There was no evidence of glomerulopathy, vasculitis or arteriosclerosis, and no active interstitial inflammation. Viable glomeruli were normocellular with open capillary loops and no increased mesangial matrix. No deposits were evident on Masson Trichrome stain. Ultrastructural evaluation demonstrated a normal glomerular capillary basement membrane thickness and no deposits. Immunofluorescence demonstrated low-intensity focal and granular deposition of IgM and C3 in the mesangia of all visualized glomeruli. Staining was negative for Kappa and Lambda light chains, IgG, IgA, albumin and C1q.Fig. 1.

Bottom Line: He reported regular matchstick consumption to prevent chigger (Trombicula autumnalis) bites, amounting to ∼5.8 g of potassium chlorate over 3 years.Potassium chlorate can cause anuric renal failure within days of a toxic dose.This case represents possible sequelae of chronic potassium chlorate ingestion.

View Article: PubMed Central - PubMed

Affiliation: Nephrology Service, Department of Medicine , Walter Reed National Military Medical Center , Bethesda, MD , USA.

ABSTRACT
We present a case of a 48-year-old active duty male soldier with a history of chronic exposure to potassium chlorate, later diagnosed with chronic interstitial nephritis. He reported regular matchstick consumption to prevent chigger (Trombicula autumnalis) bites, amounting to ∼5.8 g of potassium chlorate over 3 years. Potassium chlorate can cause anuric renal failure within days of a toxic dose. Its slow excretion and mechanism of action suggest that renal toxicity may result from lower-dose chronic exposure. This case represents possible sequelae of chronic potassium chlorate ingestion.

No MeSH data available.


Related in: MedlinePlus