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The increase in renal replacement therapy (RRT) incidence has come to an end in Sweden-analysis of variations by region over the period 1991-2010.

Qureshi AR, Evans M, Stendahl M, Prütz KG, Elinder CG - Clin Kidney J (2013)

Bottom Line: A decrease in RRT incidence was observed over the study period in eight regions.Noteworthy differences were found between counties and in 8 out of 21 counties, a decreased incidence of RRT was found.Further studies need to identify the factors that contribute to this decrease.

View Article: PubMed Central - PubMed

Affiliation: Division of Baxter Novum, Department of Clinical Science , Intervention and Technology at Karolinska Institute , Stockholm , Sweden.

ABSTRACT

Background: Renal replacement therapy (RRT) incidence has increased significantly in Sweden during the past decades. This study analyses variations in time and regional trends in RRT incidence in Sweden, adjusted for age and gender, focusing on the impact change in incidence during the last decade.

Methods: Using data from the Swedish Renal Registry (SRR) (21 counties in Sweden, total population 9 million), we identified all incident subjects starting RRT from 1991 through 2010. Only individuals alive following 90 days of RRT start were included. Gender- and age-specific standardized RRT incidences on an annual and regional basis were calculated, and differences between counties and variations over time were examined. We compared the overall age and gender-adjusted RRT incidence rates for Sweden by calendar year. Furthermore, we also calculated the age and gender-adjusted RRT incidence in each county during two time periods (1991-1999 versus 2000-2010).

Results: There were 20 172 new subjects treated with RRT between January 1991 and December 2010. The most common cause of end-stage renal disease (ESRD) was diabetes (24%) and hypertension/renal vascular disease (19%), followed by glomerulonephritis (16%). Sixty-four percent of new patients were male; the median age when commencing RRT was 66 years (10-90 percentiles; 39-80). The overall standardized RRT incidence reached its peak in 2000, and slowly decreased thereafter. A decrease in RRT incidence was observed over the study period in eight regions. The standardized RRT incidence varied between the different counties, from 0.82 to 1.19.

Conclusions: Adjusted for demographic changes in the population, an overall decrease in RRT incidence was observed from the year 2000 onwards-suggesting that the previously reported steady increase in RRT incidence is coming to an end in Sweden. Noteworthy differences were found between counties and in 8 out of 21 counties, a decreased incidence of RRT was found. Further studies need to identify the factors that contribute to this decrease.

No MeSH data available.


Related in: MedlinePlus

The standardized incidence ratio between 2000 and 2010 versus 1991 and 1999 of patients requiring RRT in various regions of Sweden. The regions marked grey are Stockholm, Skåne and Västra Götaland which are main contributors of RRT population.
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SFT032F4: The standardized incidence ratio between 2000 and 2010 versus 1991 and 1999 of patients requiring RRT in various regions of Sweden. The regions marked grey are Stockholm, Skåne and Västra Götaland which are main contributors of RRT population.

Mentions: The ratio between the age and gender-standardized incidence rates of 1991–1999 versus 2000–2010 showed a decrease in eight counties out of 21 and an increase in 15 (Figure 4)Fig. 4.


The increase in renal replacement therapy (RRT) incidence has come to an end in Sweden-analysis of variations by region over the period 1991-2010.

Qureshi AR, Evans M, Stendahl M, Prütz KG, Elinder CG - Clin Kidney J (2013)

The standardized incidence ratio between 2000 and 2010 versus 1991 and 1999 of patients requiring RRT in various regions of Sweden. The regions marked grey are Stockholm, Skåne and Västra Götaland which are main contributors of RRT population.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400478&req=5

SFT032F4: The standardized incidence ratio between 2000 and 2010 versus 1991 and 1999 of patients requiring RRT in various regions of Sweden. The regions marked grey are Stockholm, Skåne and Västra Götaland which are main contributors of RRT population.
Mentions: The ratio between the age and gender-standardized incidence rates of 1991–1999 versus 2000–2010 showed a decrease in eight counties out of 21 and an increase in 15 (Figure 4)Fig. 4.

Bottom Line: A decrease in RRT incidence was observed over the study period in eight regions.Noteworthy differences were found between counties and in 8 out of 21 counties, a decreased incidence of RRT was found.Further studies need to identify the factors that contribute to this decrease.

View Article: PubMed Central - PubMed

Affiliation: Division of Baxter Novum, Department of Clinical Science , Intervention and Technology at Karolinska Institute , Stockholm , Sweden.

ABSTRACT

Background: Renal replacement therapy (RRT) incidence has increased significantly in Sweden during the past decades. This study analyses variations in time and regional trends in RRT incidence in Sweden, adjusted for age and gender, focusing on the impact change in incidence during the last decade.

Methods: Using data from the Swedish Renal Registry (SRR) (21 counties in Sweden, total population 9 million), we identified all incident subjects starting RRT from 1991 through 2010. Only individuals alive following 90 days of RRT start were included. Gender- and age-specific standardized RRT incidences on an annual and regional basis were calculated, and differences between counties and variations over time were examined. We compared the overall age and gender-adjusted RRT incidence rates for Sweden by calendar year. Furthermore, we also calculated the age and gender-adjusted RRT incidence in each county during two time periods (1991-1999 versus 2000-2010).

Results: There were 20 172 new subjects treated with RRT between January 1991 and December 2010. The most common cause of end-stage renal disease (ESRD) was diabetes (24%) and hypertension/renal vascular disease (19%), followed by glomerulonephritis (16%). Sixty-four percent of new patients were male; the median age when commencing RRT was 66 years (10-90 percentiles; 39-80). The overall standardized RRT incidence reached its peak in 2000, and slowly decreased thereafter. A decrease in RRT incidence was observed over the study period in eight regions. The standardized RRT incidence varied between the different counties, from 0.82 to 1.19.

Conclusions: Adjusted for demographic changes in the population, an overall decrease in RRT incidence was observed from the year 2000 onwards-suggesting that the previously reported steady increase in RRT incidence is coming to an end in Sweden. Noteworthy differences were found between counties and in 8 out of 21 counties, a decreased incidence of RRT was found. Further studies need to identify the factors that contribute to this decrease.

No MeSH data available.


Related in: MedlinePlus