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Autosomal dominant polycystic kidney disease (ADPKD) is associated with coronary arterial dilatation in end-stage renal failure patients.

Chiha J, Rangan GK, Chapman JR, Thiagalingam A - Clin Kidney J (2012)

Bottom Line: Autosomal dominant polycystic kidney disease (ADPKD) can affect several organs in addition to the kidney.There is paucity in the literature on the cardiac manifestations of this disease.This retrospective study aimed to assess whether ADPKD was associated with a larger coronary artery diameter and to evaluate for the presence of coronary artery aneurysm and ectasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Westmead Hospital, Sydney, Australia ; Faculty of Medicine, University of Sydney, Sydney, Australia.

ABSTRACT
Autosomal dominant polycystic kidney disease (ADPKD) can affect several organs in addition to the kidney. There is paucity in the literature on the cardiac manifestations of this disease. This retrospective study aimed to assess whether ADPKD was associated with a larger coronary artery diameter and to evaluate for the presence of coronary artery aneurysm and ectasia. This study shows that subjects with ADPKD and end-stage renal failure have dilatation of coronary arteries independent of traditional coronary risk factors and medication use.

No MeSH data available.


Related in: MedlinePlus

Representative cine captures showing catheter calibration and measurement of the left main coronary artery. Figure 1 shows the Right Anterior Oblique 30° with 30° caudal angulation. The start and end points were chosen by the user and the length of vessel measured was 5 mm.
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fig1: Representative cine captures showing catheter calibration and measurement of the left main coronary artery. Figure 1 shows the Right Anterior Oblique 30° with 30° caudal angulation. The start and end points were chosen by the user and the length of vessel measured was 5 mm.

Mentions: Angiograms were analysed offline by a single observer (J.C.) using computerised edge-detection software (Xcelera, Philips Healthcare, Netherlands). The proximal left main coronary artery (LMCA), left anterior descending (LAD), left circumflex (LCX) and right coronary (RCA) arteries were analysed. The catheter of known diameter was used for calibration. Arterial segments were viewed in two orthogonal planes at end-diastole to maximise vessel diameter. The start and end points of a 5 mm segment of vessel were determined by the user. The average diameter within this 5 mm chosen segment was used to calculate the diameter of the proximal artery for each view. Figure 1 illustrates the method of analysis for the LMCA from one representative subject.


Autosomal dominant polycystic kidney disease (ADPKD) is associated with coronary arterial dilatation in end-stage renal failure patients.

Chiha J, Rangan GK, Chapman JR, Thiagalingam A - Clin Kidney J (2012)

Representative cine captures showing catheter calibration and measurement of the left main coronary artery. Figure 1 shows the Right Anterior Oblique 30° with 30° caudal angulation. The start and end points were chosen by the user and the length of vessel measured was 5 mm.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400451&req=5

fig1: Representative cine captures showing catheter calibration and measurement of the left main coronary artery. Figure 1 shows the Right Anterior Oblique 30° with 30° caudal angulation. The start and end points were chosen by the user and the length of vessel measured was 5 mm.
Mentions: Angiograms were analysed offline by a single observer (J.C.) using computerised edge-detection software (Xcelera, Philips Healthcare, Netherlands). The proximal left main coronary artery (LMCA), left anterior descending (LAD), left circumflex (LCX) and right coronary (RCA) arteries were analysed. The catheter of known diameter was used for calibration. Arterial segments were viewed in two orthogonal planes at end-diastole to maximise vessel diameter. The start and end points of a 5 mm segment of vessel were determined by the user. The average diameter within this 5 mm chosen segment was used to calculate the diameter of the proximal artery for each view. Figure 1 illustrates the method of analysis for the LMCA from one representative subject.

Bottom Line: Autosomal dominant polycystic kidney disease (ADPKD) can affect several organs in addition to the kidney.There is paucity in the literature on the cardiac manifestations of this disease.This retrospective study aimed to assess whether ADPKD was associated with a larger coronary artery diameter and to evaluate for the presence of coronary artery aneurysm and ectasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Westmead Hospital, Sydney, Australia ; Faculty of Medicine, University of Sydney, Sydney, Australia.

ABSTRACT
Autosomal dominant polycystic kidney disease (ADPKD) can affect several organs in addition to the kidney. There is paucity in the literature on the cardiac manifestations of this disease. This retrospective study aimed to assess whether ADPKD was associated with a larger coronary artery diameter and to evaluate for the presence of coronary artery aneurysm and ectasia. This study shows that subjects with ADPKD and end-stage renal failure have dilatation of coronary arteries independent of traditional coronary risk factors and medication use.

No MeSH data available.


Related in: MedlinePlus