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Epstein-Barr virus-associated nephrotic syndrome.

Mikhalkova D, Khanna S, Vaidya R, Sethi S, Hogan MC - Clin Kidney J (2012)

Bottom Line: Acute infection with Epstein-Barr virus (EBV) causes fever, fatigue and pharyngitis.A 22-year-old male with infectious mononucleosis (IM) presented with nephrotic syndrome.Treatment with methylprednisone led to rapid and complete clinical remission.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

ABSTRACT
Acute infection with Epstein-Barr virus (EBV) causes fever, fatigue and pharyngitis. Renal involvement in systemic EBV infections typically manifests as acute tubular necrosis or tubulointerstitial nephritis. Rarely, EBV infection causes nephrotic syndrome due to minimal change disease. A 22-year-old male with infectious mononucleosis (IM) presented with nephrotic syndrome. Renal biopsy showed minimal change disease with diffuse foot process effacement of the podocytes. Treatment with methylprednisone led to rapid and complete clinical remission. Minimal change nephropathy is a very rare manifestation of EBV infection and should be considered in patients with IM and proteinuria.

No MeSH data available.


Related in: MedlinePlus

Light microscopy showing normal glomeruli, renal tubules and interstitium. Tubular epithelial cells contained protein re-absorption granules.
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fig1: Light microscopy showing normal glomeruli, renal tubules and interstitium. Tubular epithelial cells contained protein re-absorption granules.

Mentions: A kidney biopsy was performed to further evaluate his proteinuria. Light microscopy showed well-preserved parenchyma and normal appearing glomeruli. Tubular epithelial cells contained protein re-absorption granules (Figure 1). Tissue immunofluorescence studies (IgA, IgG, IgM, C1q, C3, albumin, fibrinogen, kappa and lambda light chains) were negative. The mRNA (messenger RNA) in situ hybridization for EBV was negative. Electron microscopy revealed extensive effacement (>90%) of the foot processes of the visceral epithelial cells, consistent with minimal change disease (Figure 2).


Epstein-Barr virus-associated nephrotic syndrome.

Mikhalkova D, Khanna S, Vaidya R, Sethi S, Hogan MC - Clin Kidney J (2012)

Light microscopy showing normal glomeruli, renal tubules and interstitium. Tubular epithelial cells contained protein re-absorption granules.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400449&req=5

fig1: Light microscopy showing normal glomeruli, renal tubules and interstitium. Tubular epithelial cells contained protein re-absorption granules.
Mentions: A kidney biopsy was performed to further evaluate his proteinuria. Light microscopy showed well-preserved parenchyma and normal appearing glomeruli. Tubular epithelial cells contained protein re-absorption granules (Figure 1). Tissue immunofluorescence studies (IgA, IgG, IgM, C1q, C3, albumin, fibrinogen, kappa and lambda light chains) were negative. The mRNA (messenger RNA) in situ hybridization for EBV was negative. Electron microscopy revealed extensive effacement (>90%) of the foot processes of the visceral epithelial cells, consistent with minimal change disease (Figure 2).

Bottom Line: Acute infection with Epstein-Barr virus (EBV) causes fever, fatigue and pharyngitis.A 22-year-old male with infectious mononucleosis (IM) presented with nephrotic syndrome.Treatment with methylprednisone led to rapid and complete clinical remission.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

ABSTRACT
Acute infection with Epstein-Barr virus (EBV) causes fever, fatigue and pharyngitis. Renal involvement in systemic EBV infections typically manifests as acute tubular necrosis or tubulointerstitial nephritis. Rarely, EBV infection causes nephrotic syndrome due to minimal change disease. A 22-year-old male with infectious mononucleosis (IM) presented with nephrotic syndrome. Renal biopsy showed minimal change disease with diffuse foot process effacement of the podocytes. Treatment with methylprednisone led to rapid and complete clinical remission. Minimal change nephropathy is a very rare manifestation of EBV infection and should be considered in patients with IM and proteinuria.

No MeSH data available.


Related in: MedlinePlus