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cANCA-associated aortitis.

Amos LA, Roberts MA, Blair S, McMahon LP - Clin Kidney J (2012)

Bottom Line: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is traditionally viewed as a small vessel disease.We report a patient with cANCA antibodies directed against proteinase-3 with asymptomatic aortic involvement, in combination with diffuse alveolar haemorrhage and pauci-immune, necrotizing crescentic glomerulonephritis.A review of the literature is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Renal Medicine, Monash University and Eastern Health, Melbourne, Australia.

ABSTRACT
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is traditionally viewed as a small vessel disease. We report a patient with cANCA antibodies directed against proteinase-3 with asymptomatic aortic involvement, in combination with diffuse alveolar haemorrhage and pauci-immune, necrotizing crescentic glomerulonephritis. A review of the literature is discussed.

No MeSH data available.


Related in: MedlinePlus

Biochemical markers and response to treatment. RBC, red blood cells; HPF, high power field; PCR, protein:creatinine ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.
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fig2: Biochemical markers and response to treatment. RBC, red blood cells; HPF, high power field; PCR, protein:creatinine ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.

Mentions: Two months after discharge, investigations revealed a serum creatinine of 167 μmol/L (cANCA 30 U/mL), Figure 2. A CT aortogram showed reduced aortic inflammation (Figure 1b). Clinical remission was evident after 3 months’ treatment with cyclophosphamide, and methotrexate was commenced after the patient proved intolerant to azathioprine. Twenty months later, the patient has remained well with a serum creatinine of 115 μmol/L, with negligible haematuria (5 × 106/L erythrocytes on urine microscopy) and proteinuria (protein:creatinine ratio 0.010 g/mmol). There is no evidence of aortic vasculitis on CT scan, although the mid-thoracic and abdominal aorta remain mildly tortuous and ectatic.


cANCA-associated aortitis.

Amos LA, Roberts MA, Blair S, McMahon LP - Clin Kidney J (2012)

Biochemical markers and response to treatment. RBC, red blood cells; HPF, high power field; PCR, protein:creatinine ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400447&req=5

fig2: Biochemical markers and response to treatment. RBC, red blood cells; HPF, high power field; PCR, protein:creatinine ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.
Mentions: Two months after discharge, investigations revealed a serum creatinine of 167 μmol/L (cANCA 30 U/mL), Figure 2. A CT aortogram showed reduced aortic inflammation (Figure 1b). Clinical remission was evident after 3 months’ treatment with cyclophosphamide, and methotrexate was commenced after the patient proved intolerant to azathioprine. Twenty months later, the patient has remained well with a serum creatinine of 115 μmol/L, with negligible haematuria (5 × 106/L erythrocytes on urine microscopy) and proteinuria (protein:creatinine ratio 0.010 g/mmol). There is no evidence of aortic vasculitis on CT scan, although the mid-thoracic and abdominal aorta remain mildly tortuous and ectatic.

Bottom Line: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is traditionally viewed as a small vessel disease.We report a patient with cANCA antibodies directed against proteinase-3 with asymptomatic aortic involvement, in combination with diffuse alveolar haemorrhage and pauci-immune, necrotizing crescentic glomerulonephritis.A review of the literature is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Renal Medicine, Monash University and Eastern Health, Melbourne, Australia.

ABSTRACT
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is traditionally viewed as a small vessel disease. We report a patient with cANCA antibodies directed against proteinase-3 with asymptomatic aortic involvement, in combination with diffuse alveolar haemorrhage and pauci-immune, necrotizing crescentic glomerulonephritis. A review of the literature is discussed.

No MeSH data available.


Related in: MedlinePlus