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Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.

Rieber N, Singh A, Öz H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schäfer I, Mezger M, Klimosch SN, Weber AN, Handgretinger R, Krappmann S, Liese J, Engeholm M, Schüle R, Salih HR, Marodi L, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, Loeffler J, Hartl D - Cell Host Microbe (2015)

Bottom Line: Mechanistically, pathogenic fungi induce neutrophilic MDSCs through the pattern recognition receptor Dectin-1 and its downstream adaptor protein CARD9.Fungal MDSC induction is further dependent on pathways downstream of Dectin-1 signaling, notably reactive oxygen species (ROS) generation as well as caspase-8 activity and interleukin-1 (IL-1) production.These studies define an innate immune mechanism by which pathogenic fungi regulate host defense.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics I, University of Tübingen, 72076 Tübingen, Germany. Electronic address: nikolaus.rieber@med.uni-tuebingen.de.

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Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.

Rieber N, Singh A, Öz H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schäfer I, Mezger M, Klimosch SN, Weber AN, Handgretinger R, Krappmann S, Liese J, Engeholm M, Schüle R, Salih HR, Marodi L, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, Loeffler J, Hartl D - Cell Host Microbe (2015)

© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400268&req=5

Bottom Line: Mechanistically, pathogenic fungi induce neutrophilic MDSCs through the pattern recognition receptor Dectin-1 and its downstream adaptor protein CARD9.Fungal MDSC induction is further dependent on pathways downstream of Dectin-1 signaling, notably reactive oxygen species (ROS) generation as well as caspase-8 activity and interleukin-1 (IL-1) production.These studies define an innate immune mechanism by which pathogenic fungi regulate host defense.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics I, University of Tübingen, 72076 Tübingen, Germany. Electronic address: nikolaus.rieber@med.uni-tuebingen.de.

Show MeSH
Related in: MedlinePlus