Limits...
Anti-C1q antibodies as a follow-up marker in SLE patients.

Bock M, Heijnen I, Trendelenburg M - PLoS ONE (2015)

Bottom Line: Anti-C1q levels correlated with global disease activity scores.In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity.In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity.

View Article: PubMed Central - PubMed

Affiliation: Division of Internal Medicine, University Hospital Basel, Basel, Switzerland.

ABSTRACT
In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was to determine the value of anti-C1q as follow-up marker of disease activity and renal involvement in patients with systemic lupus erythematosus (SLE). Fifty-two patients with SLE and a minimum of three anti-C1q measurements during follow-up were analyzed. Anti-C1q levels correlated with global disease activity scores. In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity. In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity. In addition, a positive correlation with the urine protein-to-creatinine ratio and anti-dsDNA antibody levels as well as a negative correlation with complement levels was observed. Anti-C1q antibodies were found to strongly correlate with parameters of SLE disease activity during follow-up, in particular with regard to renal involvement.

No MeSH data available.


Related in: MedlinePlus

Exemplary courses of anti-C1q levels in relation to disease activity during follow up.(green: SLEDAI score, blue: ECLAM score, black: anti-C1q-level, x-axis: time points of measurement). Patients 1–8 showed an initial flare with high anti-C1q titers. After initiation of therapy disease activity as well as anti-C1q levels dropped reaching stable remission. Patients 9–16 showed flares during follow-up with either persistingly elevated levels of anti-C1q and/or a simultaneous increase of anti-C1q titers. Pat. 17 and 18 showed a stable low disease activity with concurrent low anti-C1q titers. Patients 19–24 showed a lack of correlation between disease activity and anti-C1q levels. Such a lack of correlation could be observed in patients with and without renal lupus.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4400137&req=5

pone.0123572.g002: Exemplary courses of anti-C1q levels in relation to disease activity during follow up.(green: SLEDAI score, blue: ECLAM score, black: anti-C1q-level, x-axis: time points of measurement). Patients 1–8 showed an initial flare with high anti-C1q titers. After initiation of therapy disease activity as well as anti-C1q levels dropped reaching stable remission. Patients 9–16 showed flares during follow-up with either persistingly elevated levels of anti-C1q and/or a simultaneous increase of anti-C1q titers. Pat. 17 and 18 showed a stable low disease activity with concurrent low anti-C1q titers. Patients 19–24 showed a lack of correlation between disease activity and anti-C1q levels. Such a lack of correlation could be observed in patients with and without renal lupus.

Mentions: Since anti-C1q levels varied considerably between patients with some having levels beyond the upper limit of detection whereas other patients remained low-level positive only, we evaluated individual anti-C1q levels. Characteristical follow-up curves are demonstrated in Fig 2.


Anti-C1q antibodies as a follow-up marker in SLE patients.

Bock M, Heijnen I, Trendelenburg M - PLoS ONE (2015)

Exemplary courses of anti-C1q levels in relation to disease activity during follow up.(green: SLEDAI score, blue: ECLAM score, black: anti-C1q-level, x-axis: time points of measurement). Patients 1–8 showed an initial flare with high anti-C1q titers. After initiation of therapy disease activity as well as anti-C1q levels dropped reaching stable remission. Patients 9–16 showed flares during follow-up with either persistingly elevated levels of anti-C1q and/or a simultaneous increase of anti-C1q titers. Pat. 17 and 18 showed a stable low disease activity with concurrent low anti-C1q titers. Patients 19–24 showed a lack of correlation between disease activity and anti-C1q levels. Such a lack of correlation could be observed in patients with and without renal lupus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400137&req=5

pone.0123572.g002: Exemplary courses of anti-C1q levels in relation to disease activity during follow up.(green: SLEDAI score, blue: ECLAM score, black: anti-C1q-level, x-axis: time points of measurement). Patients 1–8 showed an initial flare with high anti-C1q titers. After initiation of therapy disease activity as well as anti-C1q levels dropped reaching stable remission. Patients 9–16 showed flares during follow-up with either persistingly elevated levels of anti-C1q and/or a simultaneous increase of anti-C1q titers. Pat. 17 and 18 showed a stable low disease activity with concurrent low anti-C1q titers. Patients 19–24 showed a lack of correlation between disease activity and anti-C1q levels. Such a lack of correlation could be observed in patients with and without renal lupus.
Mentions: Since anti-C1q levels varied considerably between patients with some having levels beyond the upper limit of detection whereas other patients remained low-level positive only, we evaluated individual anti-C1q levels. Characteristical follow-up curves are demonstrated in Fig 2.

Bottom Line: Anti-C1q levels correlated with global disease activity scores.In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity.In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity.

View Article: PubMed Central - PubMed

Affiliation: Division of Internal Medicine, University Hospital Basel, Basel, Switzerland.

ABSTRACT
In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was to determine the value of anti-C1q as follow-up marker of disease activity and renal involvement in patients with systemic lupus erythematosus (SLE). Fifty-two patients with SLE and a minimum of three anti-C1q measurements during follow-up were analyzed. Anti-C1q levels correlated with global disease activity scores. In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity. In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity. In addition, a positive correlation with the urine protein-to-creatinine ratio and anti-dsDNA antibody levels as well as a negative correlation with complement levels was observed. Anti-C1q antibodies were found to strongly correlate with parameters of SLE disease activity during follow-up, in particular with regard to renal involvement.

No MeSH data available.


Related in: MedlinePlus