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Anti-C1q antibodies as a follow-up marker in SLE patients.

Bock M, Heijnen I, Trendelenburg M - PLoS ONE (2015)

Bottom Line: Anti-C1q levels correlated with global disease activity scores.In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity.In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity.

View Article: PubMed Central - PubMed

Affiliation: Division of Internal Medicine, University Hospital Basel, Basel, Switzerland.

ABSTRACT
In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was to determine the value of anti-C1q as follow-up marker of disease activity and renal involvement in patients with systemic lupus erythematosus (SLE). Fifty-two patients with SLE and a minimum of three anti-C1q measurements during follow-up were analyzed. Anti-C1q levels correlated with global disease activity scores. In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity. In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity. In addition, a positive correlation with the urine protein-to-creatinine ratio and anti-dsDNA antibody levels as well as a negative correlation with complement levels was observed. Anti-C1q antibodies were found to strongly correlate with parameters of SLE disease activity during follow-up, in particular with regard to renal involvement.

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Related in: MedlinePlus

Correlation between Anti-C1q and disease activity indices for all patients and data points.SLEDAI: R = 0.43, p<0.0001 and ECLAM: R = 0.24, p<0.0001
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pone.0123572.g001: Correlation between Anti-C1q and disease activity indices for all patients and data points.SLEDAI: R = 0.43, p<0.0001 and ECLAM: R = 0.24, p<0.0001

Mentions: With regard to disease activity, anti-C1q were found to positively correlate with disease activity as determined by ECLAM and SLEDAI scores (R = 0.24 and 0.43, respectively; p<0.0001 each). These data are demonstrated in Fig 1. For this correlation a significant albeit weak linear regression was found.


Anti-C1q antibodies as a follow-up marker in SLE patients.

Bock M, Heijnen I, Trendelenburg M - PLoS ONE (2015)

Correlation between Anti-C1q and disease activity indices for all patients and data points.SLEDAI: R = 0.43, p<0.0001 and ECLAM: R = 0.24, p<0.0001
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400137&req=5

pone.0123572.g001: Correlation between Anti-C1q and disease activity indices for all patients and data points.SLEDAI: R = 0.43, p<0.0001 and ECLAM: R = 0.24, p<0.0001
Mentions: With regard to disease activity, anti-C1q were found to positively correlate with disease activity as determined by ECLAM and SLEDAI scores (R = 0.24 and 0.43, respectively; p<0.0001 each). These data are demonstrated in Fig 1. For this correlation a significant albeit weak linear regression was found.

Bottom Line: Anti-C1q levels correlated with global disease activity scores.In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity.In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity.

View Article: PubMed Central - PubMed

Affiliation: Division of Internal Medicine, University Hospital Basel, Basel, Switzerland.

ABSTRACT
In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was to determine the value of anti-C1q as follow-up marker of disease activity and renal involvement in patients with systemic lupus erythematosus (SLE). Fifty-two patients with SLE and a minimum of three anti-C1q measurements during follow-up were analyzed. Anti-C1q levels correlated with global disease activity scores. In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity. In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity. In addition, a positive correlation with the urine protein-to-creatinine ratio and anti-dsDNA antibody levels as well as a negative correlation with complement levels was observed. Anti-C1q antibodies were found to strongly correlate with parameters of SLE disease activity during follow-up, in particular with regard to renal involvement.

No MeSH data available.


Related in: MedlinePlus