Limits...
Optic disc hemorrhage is related to various hemodynamic findings by disc angiography.

Park HY, Jeong HJ, Kim YH, Park CK - PLoS ONE (2015)

Bottom Line: Prevalence of DH and location of the proximal border were recorded from disc photographs.Arm-retina time, arteriovenous transit time, disc filling time, choroidal filling time, and venous filling time were measured as retinal circulation parameters.These findings suggest that vascular and hemodynamic changes due to glaucomatous structural changes cause DH in relation to localized RNFL defects.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Background: To investigate the hemodynamic characteristics of glaucoma eyes with disc hemorrhage (DH) by disc fluorescein angiography, and its relationship with glaucomatous changes of the optic disc and surrounding retinal nerve fiber layer (RNFL).

Methods: This study included 35 glaucoma eyes with DH who were followed up at least 5 years and had DH at presentation. Eyes were classified as eyes with DH at the border of localized RNFL defects and eyes with DH not related to localized RNFL defects. Prevalence of DH and location of the proximal border were recorded from disc photographs. Fluorescein angiography was performed 3 months after detecting the DH. Arm-retina time, arteriovenous transit time, disc filling time, choroidal filling time, and venous filling time were measured as retinal circulation parameters. The presence of disc filling defects and disc leaks were evaluated.

Results: There were 19 (54.3%) eyes with DH accompanying localized RNFL defects. The arm-retina time was prolonged in eyes with DH not related to RNFL defects (P = 0.044) and the arteriovenous transit time was prolonged in eyes with DH accompanying RNFL defects (P = 0.029). Among eyes with DH accompanying RNFL defects, 11 (57.9%) had vessel filling defects or delayed filling indicating blood flow stasis at the cup margin proximal to where DH occurred. Eyes with DH not related to RNFL defects did not show vessel filling defects or delayed filling.

Conclusions and relevance: Eyes with DH related to RNFL defects showed prolonged arteriovenous transit time and had frequent vessel filling defects or delayed filling indicating blood flow stasis and thrombus formation at the site DH occurred. These findings suggest that vascular and hemodynamic changes due to glaucomatous structural changes cause DH in relation to localized RNFL defects.

Show MeSH

Related in: MedlinePlus

A 54-year-old female with normal-tension glaucoma.Disc hemorrhage not related to a localized retinal nerve fiber layer defect shows no specific findings suggesting hemodynamic changes, such as vessel filling defect or delayed filling, disc leak, and disc filling defects.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4400035&req=5

pone.0120000.g006: A 54-year-old female with normal-tension glaucoma.Disc hemorrhage not related to a localized retinal nerve fiber layer defect shows no specific findings suggesting hemodynamic changes, such as vessel filling defect or delayed filling, disc leak, and disc filling defects.

Mentions: Another case with recurrent DH showed a disc filling defect at the inferior region of the optic disc (Fig 4). Superotemporal DH was present on fluorescein angiography, as well as a previous inferotemporal DH, both accompanying RNFL defects. A 61-year-old female case with NTG is shown in Fig 5. This eye had DH that was not related to a RNFL defect and that was located at the 9 o’clock position. In this case, we observed a thrombus at the location where the DH occurred. A case with DH not related to a RNFL defect had no apparent vessel filling defect or delayed filling, disc leak, and disc filling defects (Fig 6).


Optic disc hemorrhage is related to various hemodynamic findings by disc angiography.

Park HY, Jeong HJ, Kim YH, Park CK - PLoS ONE (2015)

A 54-year-old female with normal-tension glaucoma.Disc hemorrhage not related to a localized retinal nerve fiber layer defect shows no specific findings suggesting hemodynamic changes, such as vessel filling defect or delayed filling, disc leak, and disc filling defects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4400035&req=5

pone.0120000.g006: A 54-year-old female with normal-tension glaucoma.Disc hemorrhage not related to a localized retinal nerve fiber layer defect shows no specific findings suggesting hemodynamic changes, such as vessel filling defect or delayed filling, disc leak, and disc filling defects.
Mentions: Another case with recurrent DH showed a disc filling defect at the inferior region of the optic disc (Fig 4). Superotemporal DH was present on fluorescein angiography, as well as a previous inferotemporal DH, both accompanying RNFL defects. A 61-year-old female case with NTG is shown in Fig 5. This eye had DH that was not related to a RNFL defect and that was located at the 9 o’clock position. In this case, we observed a thrombus at the location where the DH occurred. A case with DH not related to a RNFL defect had no apparent vessel filling defect or delayed filling, disc leak, and disc filling defects (Fig 6).

Bottom Line: Prevalence of DH and location of the proximal border were recorded from disc photographs.Arm-retina time, arteriovenous transit time, disc filling time, choroidal filling time, and venous filling time were measured as retinal circulation parameters.These findings suggest that vascular and hemodynamic changes due to glaucomatous structural changes cause DH in relation to localized RNFL defects.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Background: To investigate the hemodynamic characteristics of glaucoma eyes with disc hemorrhage (DH) by disc fluorescein angiography, and its relationship with glaucomatous changes of the optic disc and surrounding retinal nerve fiber layer (RNFL).

Methods: This study included 35 glaucoma eyes with DH who were followed up at least 5 years and had DH at presentation. Eyes were classified as eyes with DH at the border of localized RNFL defects and eyes with DH not related to localized RNFL defects. Prevalence of DH and location of the proximal border were recorded from disc photographs. Fluorescein angiography was performed 3 months after detecting the DH. Arm-retina time, arteriovenous transit time, disc filling time, choroidal filling time, and venous filling time were measured as retinal circulation parameters. The presence of disc filling defects and disc leaks were evaluated.

Results: There were 19 (54.3%) eyes with DH accompanying localized RNFL defects. The arm-retina time was prolonged in eyes with DH not related to RNFL defects (P = 0.044) and the arteriovenous transit time was prolonged in eyes with DH accompanying RNFL defects (P = 0.029). Among eyes with DH accompanying RNFL defects, 11 (57.9%) had vessel filling defects or delayed filling indicating blood flow stasis at the cup margin proximal to where DH occurred. Eyes with DH not related to RNFL defects did not show vessel filling defects or delayed filling.

Conclusions and relevance: Eyes with DH related to RNFL defects showed prolonged arteriovenous transit time and had frequent vessel filling defects or delayed filling indicating blood flow stasis and thrombus formation at the site DH occurred. These findings suggest that vascular and hemodynamic changes due to glaucomatous structural changes cause DH in relation to localized RNFL defects.

Show MeSH
Related in: MedlinePlus