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From vesicles to protocells: the roles of amphiphilic molecules.

Sakuma Y, Imai M - Life (Basel) (2015)

Bottom Line: It is very challenging to construct protocells from molecular assemblies.Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation.This achievement will elucidate the pathway from molecular assembly to cellular life.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Tohoku University, Aoba, Sendai 980-8578, Japan. sakuma@bio.phys.tohoku.ac.jp.

ABSTRACT
It is very challenging to construct protocells from molecular assemblies. An important step in this challenge is the achievement of vesicle dynamics that are relevant to cellular functions, such as membrane trafficking and self-reproduction, using amphiphilic molecules. Soft matter physics will play an important role in the development of vesicles that have these functions. Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation. This achievement will elucidate the pathway from molecular assembly to cellular life.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of cyclic multilamellar vesicle growth and division (taken from [34]).
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life-05-00651-f005: Schematic diagram of cyclic multilamellar vesicle growth and division (taken from [34]).

Mentions: Another potential mechanism consists of the cyclic self-reproduction of fatty acid vesicles [34,35]. This self-reproduction process starts from spherical multilamellar oleic acid/oleate vesicles, as shown in Figure 5. By addition of oleate micelles, thin tails begin to protrude from the mother vesicle, and finally, the initially spherical vesicles completely transform into long, thread-like vesicles. By applying mild agitation (shear force), the thread-like vesicles divided into multiple smaller, spherical, multilamellar daughter vesicles. Upon further micelle addition, the daughter vesicles grow to the sphere-tail intermediate stage, and the growth-division cycle continues in a cyclic manner.


From vesicles to protocells: the roles of amphiphilic molecules.

Sakuma Y, Imai M - Life (Basel) (2015)

Schematic diagram of cyclic multilamellar vesicle growth and division (taken from [34]).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390873&req=5

life-05-00651-f005: Schematic diagram of cyclic multilamellar vesicle growth and division (taken from [34]).
Mentions: Another potential mechanism consists of the cyclic self-reproduction of fatty acid vesicles [34,35]. This self-reproduction process starts from spherical multilamellar oleic acid/oleate vesicles, as shown in Figure 5. By addition of oleate micelles, thin tails begin to protrude from the mother vesicle, and finally, the initially spherical vesicles completely transform into long, thread-like vesicles. By applying mild agitation (shear force), the thread-like vesicles divided into multiple smaller, spherical, multilamellar daughter vesicles. Upon further micelle addition, the daughter vesicles grow to the sphere-tail intermediate stage, and the growth-division cycle continues in a cyclic manner.

Bottom Line: It is very challenging to construct protocells from molecular assemblies.Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation.This achievement will elucidate the pathway from molecular assembly to cellular life.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Tohoku University, Aoba, Sendai 980-8578, Japan. sakuma@bio.phys.tohoku.ac.jp.

ABSTRACT
It is very challenging to construct protocells from molecular assemblies. An important step in this challenge is the achievement of vesicle dynamics that are relevant to cellular functions, such as membrane trafficking and self-reproduction, using amphiphilic molecules. Soft matter physics will play an important role in the development of vesicles that have these functions. Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation. This achievement will elucidate the pathway from molecular assembly to cellular life.

No MeSH data available.


Related in: MedlinePlus