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From vesicles to protocells: the roles of amphiphilic molecules.

Sakuma Y, Imai M - Life (Basel) (2015)

Bottom Line: It is very challenging to construct protocells from molecular assemblies.Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation.This achievement will elucidate the pathway from molecular assembly to cellular life.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Tohoku University, Aoba, Sendai 980-8578, Japan. sakuma@bio.phys.tohoku.ac.jp.

ABSTRACT
It is very challenging to construct protocells from molecular assemblies. An important step in this challenge is the achievement of vesicle dynamics that are relevant to cellular functions, such as membrane trafficking and self-reproduction, using amphiphilic molecules. Soft matter physics will play an important role in the development of vesicles that have these functions. Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation. This achievement will elucidate the pathway from molecular assembly to cellular life.

No MeSH data available.


Related in: MedlinePlus

A self-reproducing automaton based on Von Neumann’s logic (taken from [25]). ID, instruction tape; A, universal constructor; B, copier; C, controller; D, and self-reproducing automaton; E.
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life-05-00651-f003: A self-reproducing automaton based on Von Neumann’s logic (taken from [25]). ID, instruction tape; A, universal constructor; B, copier; C, controller; D, and self-reproducing automaton; E.

Mentions: It is worthwhile to note that the protocell concept agrees with an artificial automaton proposed by Von Neumann [24,25]. This automaton is composed of the information part (ID) and the construction part (D), as shown in Figure 3. The information part (corresponding to the gene in the protocell) is defined as a tape, which is both a code and a program. The construction part (container) contains three components, A, B and C (the reaction network of metabolism). The universal constructor (A) constructs the offspring part (D) according to the instructions encoded in the tape (ID), whereas the copier (B) replicates the instruction tape (ID). The controller (C) controls the operations of the constructor and the copier. The new automaton follows the same scheme to self-reproduce. Thus, the gene, the metabolism and the container are elementary units for an autonomous system.


From vesicles to protocells: the roles of amphiphilic molecules.

Sakuma Y, Imai M - Life (Basel) (2015)

A self-reproducing automaton based on Von Neumann’s logic (taken from [25]). ID, instruction tape; A, universal constructor; B, copier; C, controller; D, and self-reproducing automaton; E.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390873&req=5

life-05-00651-f003: A self-reproducing automaton based on Von Neumann’s logic (taken from [25]). ID, instruction tape; A, universal constructor; B, copier; C, controller; D, and self-reproducing automaton; E.
Mentions: It is worthwhile to note that the protocell concept agrees with an artificial automaton proposed by Von Neumann [24,25]. This automaton is composed of the information part (ID) and the construction part (D), as shown in Figure 3. The information part (corresponding to the gene in the protocell) is defined as a tape, which is both a code and a program. The construction part (container) contains three components, A, B and C (the reaction network of metabolism). The universal constructor (A) constructs the offspring part (D) according to the instructions encoded in the tape (ID), whereas the copier (B) replicates the instruction tape (ID). The controller (C) controls the operations of the constructor and the copier. The new automaton follows the same scheme to self-reproduce. Thus, the gene, the metabolism and the container are elementary units for an autonomous system.

Bottom Line: It is very challenging to construct protocells from molecular assemblies.Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation.This achievement will elucidate the pathway from molecular assembly to cellular life.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Tohoku University, Aoba, Sendai 980-8578, Japan. sakuma@bio.phys.tohoku.ac.jp.

ABSTRACT
It is very challenging to construct protocells from molecular assemblies. An important step in this challenge is the achievement of vesicle dynamics that are relevant to cellular functions, such as membrane trafficking and self-reproduction, using amphiphilic molecules. Soft matter physics will play an important role in the development of vesicles that have these functions. Here, we show that simple binary phospholipid vesicles have the potential to reproduce the relevant functions of adhesion, pore formation and self-reproduction of vesicles, by coupling the lipid geometries (spontaneous curvatures) and the phase separation. This achievement will elucidate the pathway from molecular assembly to cellular life.

No MeSH data available.


Related in: MedlinePlus