Limits...
From formamide to RNA, the path is tenuous but continuous.

Pino S, Sponer JE, Costanzo G, Saladino R, Mauro ED - Life (Basel) (2015)

Bottom Line: Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest.Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA.Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

View Article: PubMed Central - PubMed

Affiliation: Fondazione "Istituto Pasteur-Fondazione Cenci-Bolognetti" c/o Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" Università di Roma, P.le Aldo Moro, 5, 00185 Rome, Italy. samantapino78@libero.it.

ABSTRACT
Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

No MeSH data available.


The great track of formamide towards the first genetic molecules: cyclic nucleotides synthesized from formamide using thermal energy spontaneously self-assemble to give short oligomers. In the next step, imperfect pairing between WC-complementary strands and the transient formation of tetraloop-like overhangs could lead to the emergence of an ancient form of RNA-catalysis.
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life-05-00372-f007: The great track of formamide towards the first genetic molecules: cyclic nucleotides synthesized from formamide using thermal energy spontaneously self-assemble to give short oligomers. In the next step, imperfect pairing between WC-complementary strands and the transient formation of tetraloop-like overhangs could lead to the emergence of an ancient form of RNA-catalysis.


From formamide to RNA, the path is tenuous but continuous.

Pino S, Sponer JE, Costanzo G, Saladino R, Mauro ED - Life (Basel) (2015)

The great track of formamide towards the first genetic molecules: cyclic nucleotides synthesized from formamide using thermal energy spontaneously self-assemble to give short oligomers. In the next step, imperfect pairing between WC-complementary strands and the transient formation of tetraloop-like overhangs could lead to the emergence of an ancient form of RNA-catalysis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390857&req=5

life-05-00372-f007: The great track of formamide towards the first genetic molecules: cyclic nucleotides synthesized from formamide using thermal energy spontaneously self-assemble to give short oligomers. In the next step, imperfect pairing between WC-complementary strands and the transient formation of tetraloop-like overhangs could lead to the emergence of an ancient form of RNA-catalysis.
Bottom Line: Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest.Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA.Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

View Article: PubMed Central - PubMed

Affiliation: Fondazione "Istituto Pasteur-Fondazione Cenci-Bolognetti" c/o Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" Università di Roma, P.le Aldo Moro, 5, 00185 Rome, Italy. samantapino78@libero.it.

ABSTRACT
Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

No MeSH data available.