Limits...
From formamide to RNA, the path is tenuous but continuous.

Pino S, Sponer JE, Costanzo G, Saladino R, Mauro ED - Life (Basel) (2015)

Bottom Line: Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest.Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA.Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

View Article: PubMed Central - PubMed

Affiliation: Fondazione "Istituto Pasteur-Fondazione Cenci-Bolognetti" c/o Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" Università di Roma, P.le Aldo Moro, 5, 00185 Rome, Italy. samantapino78@libero.it.

ABSTRACT
Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

No MeSH data available.


The mechanism of polymerization of 3',5'-cGMP (see [33]).
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life-05-00372-f003: The mechanism of polymerization of 3',5'-cGMP (see [33]).

Mentions: Based on the measured stacking of the 3',5'-cyclic monomers [33], the activation of the reaction by Brønsted bases and the determination of the molecular species produced, a reaction pathway was proposed [33] consisting of a simple process based on the formation of base stacking-supported pillared structures, followed by position-stimulated polymerization by trans-phosphorylation (Figure 3).


From formamide to RNA, the path is tenuous but continuous.

Pino S, Sponer JE, Costanzo G, Saladino R, Mauro ED - Life (Basel) (2015)

The mechanism of polymerization of 3',5'-cGMP (see [33]).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390857&req=5

life-05-00372-f003: The mechanism of polymerization of 3',5'-cGMP (see [33]).
Mentions: Based on the measured stacking of the 3',5'-cyclic monomers [33], the activation of the reaction by Brønsted bases and the determination of the molecular species produced, a reaction pathway was proposed [33] consisting of a simple process based on the formation of base stacking-supported pillared structures, followed by position-stimulated polymerization by trans-phosphorylation (Figure 3).

Bottom Line: Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest.Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA.Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

View Article: PubMed Central - PubMed

Affiliation: Fondazione "Istituto Pasteur-Fondazione Cenci-Bolognetti" c/o Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" Università di Roma, P.le Aldo Moro, 5, 00185 Rome, Italy. samantapino78@libero.it.

ABSTRACT
Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

No MeSH data available.