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Lead excretion in spanish children with autism spectrum disorder.

Fuentes-Albero M, Puig-Alcaraz C, Cauli O - Brain Sci (2015)

Bottom Line: The study was performed in a group of children with ASD (n = 35, average age 7.4 ± 0.5 years) and TD (n = 34, average age 7.7 ± 0.9 years).Measurement of lead in urine was performed by atomic absorption spectrometry; symptoms of ASD were analyzed by diagnostic and statistical manual of mental disorders (DMS-IV) using the questionnary ADI-R.Careful clinical evaluation was also undertaken and statistical analysis was done taking into account any possible confounding factor.

View Article: PubMed Central - PubMed

Affiliation: Children's Mental Health Centre, Hospital Arnau de Villanova, 46015 Valencia, Spain. milafuentesalbero@yahoo.es.

ABSTRACT
Among epigenetic factors leading to increased prevalence of juvenile neuropsychiatric disorders, including autism spectrum disorder, exposure to metals, such as lead (Pb) have led to conflicting results. The aim of the present study was to determine the levels of Pb in the urine of children with autism spectrum disorder (ASD) compared with typically developing children (TD) age- and sex-matched, and to analyze any association between core symptoms of ASD, special diets, supplements intake or prescription drugs and the concentration of Pb. The study was performed in a group of children with ASD (n = 35, average age 7.4 ± 0.5 years) and TD (n = 34, average age 7.7 ± 0.9 years). Measurement of lead in urine was performed by atomic absorption spectrometry; symptoms of ASD were analyzed by diagnostic and statistical manual of mental disorders (DMS-IV) using the questionnary ADI-R. Careful clinical evaluation was also undertaken and statistical analysis was done taking into account any possible confounding factor.

No MeSH data available.


Related in: MedlinePlus

Correlation between the score in the socialization (A); communication (B); and stereotyped/restricted activities (C) and total the revised autism diagnostic interview™ (ADI-R) autism score (D) and urinary concentration of Pb.
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brainsci-05-00058-f002: Correlation between the score in the socialization (A); communication (B); and stereotyped/restricted activities (C) and total the revised autism diagnostic interview™ (ADI-R) autism score (D) and urinary concentration of Pb.

Mentions: No significant correlation was found between socialization deficit scores assessed with ADI-R and the concentration of Pb in urine (Spearman r = 0.12, p = 0.54; Figure 2A) or with the communication deficit scores in urine (Spearman r = 0.08, p = 0.67; Figure 2B) or with repetitive/restricted behavior scores (Spearman r = 0.21, p = 0.27; Figure 2C). No significant correlation was found between total ADI-R score and Pb concentration (Spearman r = 0.06, p = 0.76; Figure 2D) with the concentration of Pb in urine in children with ASD.


Lead excretion in spanish children with autism spectrum disorder.

Fuentes-Albero M, Puig-Alcaraz C, Cauli O - Brain Sci (2015)

Correlation between the score in the socialization (A); communication (B); and stereotyped/restricted activities (C) and total the revised autism diagnostic interview™ (ADI-R) autism score (D) and urinary concentration of Pb.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390791&req=5

brainsci-05-00058-f002: Correlation between the score in the socialization (A); communication (B); and stereotyped/restricted activities (C) and total the revised autism diagnostic interview™ (ADI-R) autism score (D) and urinary concentration of Pb.
Mentions: No significant correlation was found between socialization deficit scores assessed with ADI-R and the concentration of Pb in urine (Spearman r = 0.12, p = 0.54; Figure 2A) or with the communication deficit scores in urine (Spearman r = 0.08, p = 0.67; Figure 2B) or with repetitive/restricted behavior scores (Spearman r = 0.21, p = 0.27; Figure 2C). No significant correlation was found between total ADI-R score and Pb concentration (Spearman r = 0.06, p = 0.76; Figure 2D) with the concentration of Pb in urine in children with ASD.

Bottom Line: The study was performed in a group of children with ASD (n = 35, average age 7.4 ± 0.5 years) and TD (n = 34, average age 7.7 ± 0.9 years).Measurement of lead in urine was performed by atomic absorption spectrometry; symptoms of ASD were analyzed by diagnostic and statistical manual of mental disorders (DMS-IV) using the questionnary ADI-R.Careful clinical evaluation was also undertaken and statistical analysis was done taking into account any possible confounding factor.

View Article: PubMed Central - PubMed

Affiliation: Children's Mental Health Centre, Hospital Arnau de Villanova, 46015 Valencia, Spain. milafuentesalbero@yahoo.es.

ABSTRACT
Among epigenetic factors leading to increased prevalence of juvenile neuropsychiatric disorders, including autism spectrum disorder, exposure to metals, such as lead (Pb) have led to conflicting results. The aim of the present study was to determine the levels of Pb in the urine of children with autism spectrum disorder (ASD) compared with typically developing children (TD) age- and sex-matched, and to analyze any association between core symptoms of ASD, special diets, supplements intake or prescription drugs and the concentration of Pb. The study was performed in a group of children with ASD (n = 35, average age 7.4 ± 0.5 years) and TD (n = 34, average age 7.7 ± 0.9 years). Measurement of lead in urine was performed by atomic absorption spectrometry; symptoms of ASD were analyzed by diagnostic and statistical manual of mental disorders (DMS-IV) using the questionnary ADI-R. Careful clinical evaluation was also undertaken and statistical analysis was done taking into account any possible confounding factor.

No MeSH data available.


Related in: MedlinePlus