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Clinical Significance of B-type Natriuretic Peptide in Heart Failure.

Yoo BS - J Lifestyle Med (2014)

Bottom Line: Biochemical tests to detect B-type natriuretic peptide (BNP) or N-terminal pro-brain BNP (NT-proBNP) are useful diagnostic methods for patients with possible HF.These tests are valuable prognostic predictors for the entire spectrum of HF disease severity.The following review briefly summarizes the available information regarding the clinical significance of BNP and NT-proBNP.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.

ABSTRACT
Biochemical tests to detect B-type natriuretic peptide (BNP) or N-terminal pro-brain BNP (NT-proBNP) are useful diagnostic methods for patients with possible HF. These tests are valuable prognostic predictors for the entire spectrum of HF disease severity. Therefore, the measurements of BNP or NT-proBNP taken along with conventional clinical assessments may assist clinicians in deciding treatment. The following review briefly summarizes the available information regarding the clinical significance of BNP and NT-proBNP.

No MeSH data available.


Percent reduction in N-terminal pro-brain BNP (NT-proBNP) levels according to the clinical course during hospitalization [12].
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f2-jlm-04-34: Percent reduction in N-terminal pro-brain BNP (NT-proBNP) levels according to the clinical course during hospitalization [12].

Mentions: BNP is assumed to have a mechanism similar to a biochemical Swan-Ganz catheter and is thought to play a role similar to that of hemoglobin A1c in patients with diabetes mellitus or α-fetoprotein in patients with hepatoma. The development of various drugs that mitigate the course or symptoms of heart failure have prompted many discussions about the monitoring of therapeutic reactions or the possibility of drug titration. In a study on NT-proBNP, Lopez et al. reported that its concentration decreased by 21% in patients who maintained continuously decompensated heart failure, decreased by 37% in patients who maintained stable chronic heart failure, and decreased by approximately 56% in patients who fully recovered (Fig. 2) [12]. Further large-scale randomized clinical trials are required to determine whether this kind of monitoring can serve as a standard for therapeutic decision-making and drug dosage. However, the extent of NT-proBNP reduction is obviously associated with clinical improvement.


Clinical Significance of B-type Natriuretic Peptide in Heart Failure.

Yoo BS - J Lifestyle Med (2014)

Percent reduction in N-terminal pro-brain BNP (NT-proBNP) levels according to the clinical course during hospitalization [12].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390764&req=5

f2-jlm-04-34: Percent reduction in N-terminal pro-brain BNP (NT-proBNP) levels according to the clinical course during hospitalization [12].
Mentions: BNP is assumed to have a mechanism similar to a biochemical Swan-Ganz catheter and is thought to play a role similar to that of hemoglobin A1c in patients with diabetes mellitus or α-fetoprotein in patients with hepatoma. The development of various drugs that mitigate the course or symptoms of heart failure have prompted many discussions about the monitoring of therapeutic reactions or the possibility of drug titration. In a study on NT-proBNP, Lopez et al. reported that its concentration decreased by 21% in patients who maintained continuously decompensated heart failure, decreased by 37% in patients who maintained stable chronic heart failure, and decreased by approximately 56% in patients who fully recovered (Fig. 2) [12]. Further large-scale randomized clinical trials are required to determine whether this kind of monitoring can serve as a standard for therapeutic decision-making and drug dosage. However, the extent of NT-proBNP reduction is obviously associated with clinical improvement.

Bottom Line: Biochemical tests to detect B-type natriuretic peptide (BNP) or N-terminal pro-brain BNP (NT-proBNP) are useful diagnostic methods for patients with possible HF.These tests are valuable prognostic predictors for the entire spectrum of HF disease severity.The following review briefly summarizes the available information regarding the clinical significance of BNP and NT-proBNP.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.

ABSTRACT
Biochemical tests to detect B-type natriuretic peptide (BNP) or N-terminal pro-brain BNP (NT-proBNP) are useful diagnostic methods for patients with possible HF. These tests are valuable prognostic predictors for the entire spectrum of HF disease severity. Therefore, the measurements of BNP or NT-proBNP taken along with conventional clinical assessments may assist clinicians in deciding treatment. The following review briefly summarizes the available information regarding the clinical significance of BNP and NT-proBNP.

No MeSH data available.