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Cutaneous Immune Defenses Against Staphylococcus aureus Infections.

Choi JH, Seo HS, Lim SY, Park K - J Lifestyle Med (2014)

Bottom Line: Staphylococcus aureus (S. aureus) is a virulent bacterium that abundantly colonizes inflammatory skin diseases.In this review, we summarize not only the pathogenesis and key elements of S. aureus skin infections, but also the cutaneous immune system against its infections and colonization.The information obtained from this area may provide the groundwork for further immunomodulatory therapies or vaccination strategies to prevent S. aureus infections.

View Article: PubMed Central - PubMed

Affiliation: Research Division for Biotechnology, Korea Atomic Energy Research Institute, Jeongeup, Korea;

ABSTRACT
Staphylococcus aureus (S. aureus) is a virulent bacterium that abundantly colonizes inflammatory skin diseases. Since S. aureus infections occur in an impaired skin barrier, it is important to understand the protective mechanism through cutaneous immune responses against S. aureus infections and the interaction with Staphylococcal virulence factors. In this review, we summarize not only the pathogenesis and key elements of S. aureus skin infections, but also the cutaneous immune system against its infections and colonization. The information obtained from this area may provide the groundwork for further immunomodulatory therapies or vaccination strategies to prevent S. aureus infections.

No MeSH data available.


Related in: MedlinePlus

Virulent factors of S. aureus.
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f1-jlm-04-39: Virulent factors of S. aureus.

Mentions: S. aureus is a gram-positive opportunistic pathogen that is normally found on the skin and nose of appropriately 25–30% of healthy adults and in 25% of hospital workers [9,10]. Colonization provides a reservoir from which bacteria can be introduced, usually resulting in a localized collection of pus, known as an abscess or furuncle, cellulitis, impetigo, and scalded skin syndrome [11]. Once S. aureus disseminate into the bloodstream and spread to the organs, the organism spreads widely to peripheral sites in the distant organs, leading to serious illnesses known as bacteremia, sepsis, osteomyelitis, and infective endocarditis [12,13]. The prevalence of these infections has apparently increased owing to higher rates of colonization, immunosuppression, a greater use of surgical implants, and dramatic increases in antibiotic resistance [3]. It is critical to understand the mechanisms of skin S. aureus colonization, which is an important risk factor for subsequent infection (Fig. 1).


Cutaneous Immune Defenses Against Staphylococcus aureus Infections.

Choi JH, Seo HS, Lim SY, Park K - J Lifestyle Med (2014)

Virulent factors of S. aureus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390763&req=5

f1-jlm-04-39: Virulent factors of S. aureus.
Mentions: S. aureus is a gram-positive opportunistic pathogen that is normally found on the skin and nose of appropriately 25–30% of healthy adults and in 25% of hospital workers [9,10]. Colonization provides a reservoir from which bacteria can be introduced, usually resulting in a localized collection of pus, known as an abscess or furuncle, cellulitis, impetigo, and scalded skin syndrome [11]. Once S. aureus disseminate into the bloodstream and spread to the organs, the organism spreads widely to peripheral sites in the distant organs, leading to serious illnesses known as bacteremia, sepsis, osteomyelitis, and infective endocarditis [12,13]. The prevalence of these infections has apparently increased owing to higher rates of colonization, immunosuppression, a greater use of surgical implants, and dramatic increases in antibiotic resistance [3]. It is critical to understand the mechanisms of skin S. aureus colonization, which is an important risk factor for subsequent infection (Fig. 1).

Bottom Line: Staphylococcus aureus (S. aureus) is a virulent bacterium that abundantly colonizes inflammatory skin diseases.In this review, we summarize not only the pathogenesis and key elements of S. aureus skin infections, but also the cutaneous immune system against its infections and colonization.The information obtained from this area may provide the groundwork for further immunomodulatory therapies or vaccination strategies to prevent S. aureus infections.

View Article: PubMed Central - PubMed

Affiliation: Research Division for Biotechnology, Korea Atomic Energy Research Institute, Jeongeup, Korea;

ABSTRACT
Staphylococcus aureus (S. aureus) is a virulent bacterium that abundantly colonizes inflammatory skin diseases. Since S. aureus infections occur in an impaired skin barrier, it is important to understand the protective mechanism through cutaneous immune responses against S. aureus infections and the interaction with Staphylococcal virulence factors. In this review, we summarize not only the pathogenesis and key elements of S. aureus skin infections, but also the cutaneous immune system against its infections and colonization. The information obtained from this area may provide the groundwork for further immunomodulatory therapies or vaccination strategies to prevent S. aureus infections.

No MeSH data available.


Related in: MedlinePlus