Limits...
Current Concepts of Premature Ventricular Contractions.

Ahn MS - J Lifestyle Med (2013)

Bottom Line: Especially in ischemic heart disease, the frequency and complexity of PVCs is associated with mortality.In congestive heart failure, PVCs did not provide significant incremental prognostic information beyond readily available clinical variables.Recently, the concept of PVC-induced cardiomyopathy was proposed when pharmacological suppression of PVCs in patients with presumed idiopathic dilated cardiomyopathy subsequently showed improved left ventricular systolic dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

ABSTRACT
Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricle. PVCs are common with an estimated prevalence of 40% to 75% in the general population on 24- to 48-hour Holter monitoring. Traditionally, they have been thought to be relatively benign in the absence of structural heart disease but they represent increased risk of sudden death in structural heart disease. Especially in ischemic heart disease, the frequency and complexity of PVCs is associated with mortality. Implantable cardioverter defibrillator therapy is indicated in patients with nonsustained ventricular tachycardia (NSVT) due to prior myocardial infarction, left ventricular ejection fraction less than or equal to 40%, and inducible ventricular fibrillation or sustained ventricular tachycardia at electrophysiological study. In congestive heart failure, PVCs did not provide significant incremental prognostic information beyond readily available clinical variables. Consequently, NSVT should not guide therapeutic interventions. Recently, the concept of PVC-induced cardiomyopathy was proposed when pharmacological suppression of PVCs in patients with presumed idiopathic dilated cardiomyopathy subsequently showed improved left ventricular systolic dysfunction. For the treatment PVCs, it is important to consider underlying heart disease, the frequency of the PVCs and the frequency and severity of symptoms.

No MeSH data available.


Related in: MedlinePlus

Example of premature ventricular complex.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4390755&req=5

f1-jlm-03-26: Example of premature ventricular complex.

Mentions: Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricle (Fig. 1). PVCs are common with an estimated prevalence of 1% to 4% in the general population on standard 12-lead electrocardiography and between 40% and 75% of subjects on 24- to 48-hour Holter monitoring [1,2]. Ventricular ectopic activity occurs in a wide variety of clinical settings with a spectrum of clinical implications. They are often seen in association with structural heart disease and represent increased risk of sudden death, yet they are ubiquitous, even in the absence of identifiable heart disease [3,4]. Traditionally, they have been thought to be relatively benign in the absence of structural heart disease [2,5]. Over the last decade, however, PVC-induced cardiomyopathy (CMP) has been a subject of great interest and the evidence for this entity is rapidly emerging. Appropriate clinical evaluation and investigations are important in assessing patients with PVCs so that effective treatment can be targeted when necessary. This article discusses the current knowledge and practice in this commonly encountered clinical cardiological problem.


Current Concepts of Premature Ventricular Contractions.

Ahn MS - J Lifestyle Med (2013)

Example of premature ventricular complex.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390755&req=5

f1-jlm-03-26: Example of premature ventricular complex.
Mentions: Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricle (Fig. 1). PVCs are common with an estimated prevalence of 1% to 4% in the general population on standard 12-lead electrocardiography and between 40% and 75% of subjects on 24- to 48-hour Holter monitoring [1,2]. Ventricular ectopic activity occurs in a wide variety of clinical settings with a spectrum of clinical implications. They are often seen in association with structural heart disease and represent increased risk of sudden death, yet they are ubiquitous, even in the absence of identifiable heart disease [3,4]. Traditionally, they have been thought to be relatively benign in the absence of structural heart disease [2,5]. Over the last decade, however, PVC-induced cardiomyopathy (CMP) has been a subject of great interest and the evidence for this entity is rapidly emerging. Appropriate clinical evaluation and investigations are important in assessing patients with PVCs so that effective treatment can be targeted when necessary. This article discusses the current knowledge and practice in this commonly encountered clinical cardiological problem.

Bottom Line: Especially in ischemic heart disease, the frequency and complexity of PVCs is associated with mortality.In congestive heart failure, PVCs did not provide significant incremental prognostic information beyond readily available clinical variables.Recently, the concept of PVC-induced cardiomyopathy was proposed when pharmacological suppression of PVCs in patients with presumed idiopathic dilated cardiomyopathy subsequently showed improved left ventricular systolic dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

ABSTRACT
Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricle. PVCs are common with an estimated prevalence of 40% to 75% in the general population on 24- to 48-hour Holter monitoring. Traditionally, they have been thought to be relatively benign in the absence of structural heart disease but they represent increased risk of sudden death in structural heart disease. Especially in ischemic heart disease, the frequency and complexity of PVCs is associated with mortality. Implantable cardioverter defibrillator therapy is indicated in patients with nonsustained ventricular tachycardia (NSVT) due to prior myocardial infarction, left ventricular ejection fraction less than or equal to 40%, and inducible ventricular fibrillation or sustained ventricular tachycardia at electrophysiological study. In congestive heart failure, PVCs did not provide significant incremental prognostic information beyond readily available clinical variables. Consequently, NSVT should not guide therapeutic interventions. Recently, the concept of PVC-induced cardiomyopathy was proposed when pharmacological suppression of PVCs in patients with presumed idiopathic dilated cardiomyopathy subsequently showed improved left ventricular systolic dysfunction. For the treatment PVCs, it is important to consider underlying heart disease, the frequency of the PVCs and the frequency and severity of symptoms.

No MeSH data available.


Related in: MedlinePlus