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Regulation of IGFBP-1 in Metabolic Diseases.

Bae JH, Song DK, Im SS - J Lifestyle Med (2013)

Bottom Line: Also, the complex regulatory mechanisms involved in both transcription and translation of IGFBPs provide evidence for molecular mechanisms by which growth factor- and hormone-mediated gene expression are regulated.In particular, IGFBP-1 is known to be an important regulator of IGF activity and mainly regulates metabolism in mammals.In this review, we focus on recent progress in elucidating the transcriptional regulation of IGFBP-1 among IGFBP isoforms.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Keimyung University School of Medicine, Daegu, Korea.

ABSTRACT
Insulin-like growth factor binding proteins (IGFBPs) play a key role in insulin and insulin growth factor signaling and are known to be expressed in several tissues. Studies on the transcriptional regulation of IGFBP genes in various cell types have suggested that IGFBPs control both systemic hormones and regulators. Also, the complex regulatory mechanisms involved in both transcription and translation of IGFBPs provide evidence for molecular mechanisms by which growth factor- and hormone-mediated gene expression are regulated. In particular, IGFBP-1 is known to be an important regulator of IGF activity and mainly regulates metabolism in mammals. In this review, we focus on recent progress in elucidating the transcriptional regulation of IGFBP-1 among IGFBP isoforms.

No MeSH data available.


Location of IGFBPs.
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f1-jlm-03-73: Location of IGFBPs.

Mentions: The mammalian IGFBP genes have been duplicated by chromosome copying since 1993 when locations of IGFBP-1 and 2 genes were identified in the same regions as housekeeping gene clusters on human chromosomes 7 and 2 [15]. The location of the IGFBP family is described in Fig. 1. The evolutionary relationship between the different IGFBP isoforms is well explained by genome duplication in vertebrates [16]. Along with the historical aspect for the analysis of IGFBP evolution, there are also functional implications when considering genome duplications. IGFBPs form part of the growth-activating hormonal axis with IGFs, which are released into the blood by the action of growth hormone. IGFBP-1 is located on the short arm of chromosome 7 and encoded by a 5.31 kb gene. IGFBP-1 has a molecular weight of about 25 kDa and circulates in plasma as a heterodimer complex with IGF-1 or II. IGFBP-1 is present in the amniotic fluid at concentrations 100–500 times higher than in plasma [11].


Regulation of IGFBP-1 in Metabolic Diseases.

Bae JH, Song DK, Im SS - J Lifestyle Med (2013)

Location of IGFBPs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390745&req=5

f1-jlm-03-73: Location of IGFBPs.
Mentions: The mammalian IGFBP genes have been duplicated by chromosome copying since 1993 when locations of IGFBP-1 and 2 genes were identified in the same regions as housekeeping gene clusters on human chromosomes 7 and 2 [15]. The location of the IGFBP family is described in Fig. 1. The evolutionary relationship between the different IGFBP isoforms is well explained by genome duplication in vertebrates [16]. Along with the historical aspect for the analysis of IGFBP evolution, there are also functional implications when considering genome duplications. IGFBPs form part of the growth-activating hormonal axis with IGFs, which are released into the blood by the action of growth hormone. IGFBP-1 is located on the short arm of chromosome 7 and encoded by a 5.31 kb gene. IGFBP-1 has a molecular weight of about 25 kDa and circulates in plasma as a heterodimer complex with IGF-1 or II. IGFBP-1 is present in the amniotic fluid at concentrations 100–500 times higher than in plasma [11].

Bottom Line: Also, the complex regulatory mechanisms involved in both transcription and translation of IGFBPs provide evidence for molecular mechanisms by which growth factor- and hormone-mediated gene expression are regulated.In particular, IGFBP-1 is known to be an important regulator of IGF activity and mainly regulates metabolism in mammals.In this review, we focus on recent progress in elucidating the transcriptional regulation of IGFBP-1 among IGFBP isoforms.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Keimyung University School of Medicine, Daegu, Korea.

ABSTRACT
Insulin-like growth factor binding proteins (IGFBPs) play a key role in insulin and insulin growth factor signaling and are known to be expressed in several tissues. Studies on the transcriptional regulation of IGFBP genes in various cell types have suggested that IGFBPs control both systemic hormones and regulators. Also, the complex regulatory mechanisms involved in both transcription and translation of IGFBPs provide evidence for molecular mechanisms by which growth factor- and hormone-mediated gene expression are regulated. In particular, IGFBP-1 is known to be an important regulator of IGF activity and mainly regulates metabolism in mammals. In this review, we focus on recent progress in elucidating the transcriptional regulation of IGFBP-1 among IGFBP isoforms.

No MeSH data available.