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TGFβ Signaling-mediated MicroRNA Regulation in Vascular Smooth Muscle Cells.

Kim S, Kang H - J Lifestyle Med (2013)

Bottom Line: Recently, it has been recognized that regulation of each step of miRNA biogenesis is critical for generating functional miRNAs.TGFβ signaling regulates expression of several miRNAs that are implicated in the development and homeostasis of vascular smooth muscle cells (VSMCs).This review describes recent understanding of the transcriptional and post-transcriptional regulation of miRNA expression by TGF β signaling in VSMCs.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Dermatology-Immunology, College of Medicine, The Catholic University of Korea, Seoul.

ABSTRACT
The discovery of small noncoding microRNAs (miRNAs) increases the complexity of gene expression regulatory mechanisms. The basic mechanism of miRNA biogenesis and regulatory functions of target genes have been widely elucidated. Recently, it has been recognized that regulation of each step of miRNA biogenesis is critical for generating functional miRNAs. Interestingly, cell signaling pathways, including the transforming growth factor β (TGFβ) signaling pathway, have been found to modulate miRNA biosynthesis. TGFβ signaling regulates expression of several miRNAs that are implicated in the development and homeostasis of vascular smooth muscle cells (VSMCs). This review describes recent understanding of the transcriptional and post-transcriptional regulation of miRNA expression by TGF β signaling in VSMCs.

No MeSH data available.


Related in: MedlinePlus

Regulation of miRNA by TGFβ signaling. The TGFβ family of ligands causes phosphorylation and translocation of Smads into the nucleus. Transcription of miRNA can be regulated by direct binding of Smads to the promoter region (Smad binding element, SBE) of a miRNA gene. Alternatively, miRNA processing can be modulated by association of Smads with pri-miRNAs.
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f1-jlm-03-80: Regulation of miRNA by TGFβ signaling. The TGFβ family of ligands causes phosphorylation and translocation of Smads into the nucleus. Transcription of miRNA can be regulated by direct binding of Smads to the promoter region (Smad binding element, SBE) of a miRNA gene. Alternatively, miRNA processing can be modulated by association of Smads with pri-miRNAs.

Mentions: Recently, it has been reported that TGFβ signaling pathway can regulate the biogenesis of small noncoding miRNAs [24]. Expression of miRNAs can be transcriptionally controlled by TGFβ signaling, similarly to mRNAs, or post-transcriptionally in either of the processing steps (Fig. 1).


TGFβ Signaling-mediated MicroRNA Regulation in Vascular Smooth Muscle Cells.

Kim S, Kang H - J Lifestyle Med (2013)

Regulation of miRNA by TGFβ signaling. The TGFβ family of ligands causes phosphorylation and translocation of Smads into the nucleus. Transcription of miRNA can be regulated by direct binding of Smads to the promoter region (Smad binding element, SBE) of a miRNA gene. Alternatively, miRNA processing can be modulated by association of Smads with pri-miRNAs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390744&req=5

f1-jlm-03-80: Regulation of miRNA by TGFβ signaling. The TGFβ family of ligands causes phosphorylation and translocation of Smads into the nucleus. Transcription of miRNA can be regulated by direct binding of Smads to the promoter region (Smad binding element, SBE) of a miRNA gene. Alternatively, miRNA processing can be modulated by association of Smads with pri-miRNAs.
Mentions: Recently, it has been reported that TGFβ signaling pathway can regulate the biogenesis of small noncoding miRNAs [24]. Expression of miRNAs can be transcriptionally controlled by TGFβ signaling, similarly to mRNAs, or post-transcriptionally in either of the processing steps (Fig. 1).

Bottom Line: Recently, it has been recognized that regulation of each step of miRNA biogenesis is critical for generating functional miRNAs.TGFβ signaling regulates expression of several miRNAs that are implicated in the development and homeostasis of vascular smooth muscle cells (VSMCs).This review describes recent understanding of the transcriptional and post-transcriptional regulation of miRNA expression by TGF β signaling in VSMCs.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Dermatology-Immunology, College of Medicine, The Catholic University of Korea, Seoul.

ABSTRACT
The discovery of small noncoding microRNAs (miRNAs) increases the complexity of gene expression regulatory mechanisms. The basic mechanism of miRNA biogenesis and regulatory functions of target genes have been widely elucidated. Recently, it has been recognized that regulation of each step of miRNA biogenesis is critical for generating functional miRNAs. Interestingly, cell signaling pathways, including the transforming growth factor β (TGFβ) signaling pathway, have been found to modulate miRNA biosynthesis. TGFβ signaling regulates expression of several miRNAs that are implicated in the development and homeostasis of vascular smooth muscle cells (VSMCs). This review describes recent understanding of the transcriptional and post-transcriptional regulation of miRNA expression by TGF β signaling in VSMCs.

No MeSH data available.


Related in: MedlinePlus