Limits...
Hyperuricemia as a Potential Determinant of Metabolic Syndrome.

Yadav D, Lee ES, Kim HM, Lee EY, Choi E, Chung CH - J Lifestyle Med (2013)

Bottom Line: In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level.High level of uric acid has been associated with metabolic syndrome, type 2 diabetes and cardiovascular diseases.Hyperuricemia has attributed to hyperinsulinemia in metabolic syndrome and decreased excretion of uric acid causing endothelial dysfunction in kidney leads to renal disease and cardiovascular disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju.

ABSTRACT
Recent studies have focused on hyperuricemia as a modulator for metabolic syndrome. Hyperuricemia has reported in many studies as a causal marker in a higher prevalence of metabolic syndrome. In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level. High level of uric acid has been associated with metabolic syndrome, type 2 diabetes and cardiovascular diseases. Hyperuricemia has attributed to hyperinsulinemia in metabolic syndrome and decreased excretion of uric acid causing endothelial dysfunction in kidney leads to renal disease and cardiovascular disorders. This review focus on the role of uric acid in the development of metabolic syndrome and onthe possible pathophysiology.

No MeSH data available.


Related in: MedlinePlus

Multiple bidirectional association between higher level of uric acid and different component of metabolic syndrome. Insulin resistance is a central component that is associated with hyperuricemia and further development of metabolic syndrome. Hyperuricemia may develop metabolic syndrome by inducing endothelial dysfunction and also through activating proinflammatory pathways.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4390742&req=5

f1-jlm-03-98: Multiple bidirectional association between higher level of uric acid and different component of metabolic syndrome. Insulin resistance is a central component that is associated with hyperuricemia and further development of metabolic syndrome. Hyperuricemia may develop metabolic syndrome by inducing endothelial dysfunction and also through activating proinflammatory pathways.

Mentions: Waist circumference have been suggested as a measure of intra-abdominal fat mass, body mass index and waist-to-hip ratio is a simple indicator for the assessment of cardiovascular risk [37,38]. Indeed the prevalence of insulin resistance is increased in overweight/obese individuals [39,40]. The association of insulin resistance and obesity leads to the further development of the other factors of metabolic syndrome. Wajchenberg suggested that insulin resistance in adipose tissue leads to an inability to suppress the release of fatty acids from adipose tissue and thus it induced decrease in the clearance of triglyceride-rich lipoproteins [41]. Ultimately, abdominal obesity associated with insulin resistance and triglyceride may increase the uric acid level by the decreased insulin sensitivity (Fig. 1).


Hyperuricemia as a Potential Determinant of Metabolic Syndrome.

Yadav D, Lee ES, Kim HM, Lee EY, Choi E, Chung CH - J Lifestyle Med (2013)

Multiple bidirectional association between higher level of uric acid and different component of metabolic syndrome. Insulin resistance is a central component that is associated with hyperuricemia and further development of metabolic syndrome. Hyperuricemia may develop metabolic syndrome by inducing endothelial dysfunction and also through activating proinflammatory pathways.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390742&req=5

f1-jlm-03-98: Multiple bidirectional association between higher level of uric acid and different component of metabolic syndrome. Insulin resistance is a central component that is associated with hyperuricemia and further development of metabolic syndrome. Hyperuricemia may develop metabolic syndrome by inducing endothelial dysfunction and also through activating proinflammatory pathways.
Mentions: Waist circumference have been suggested as a measure of intra-abdominal fat mass, body mass index and waist-to-hip ratio is a simple indicator for the assessment of cardiovascular risk [37,38]. Indeed the prevalence of insulin resistance is increased in overweight/obese individuals [39,40]. The association of insulin resistance and obesity leads to the further development of the other factors of metabolic syndrome. Wajchenberg suggested that insulin resistance in adipose tissue leads to an inability to suppress the release of fatty acids from adipose tissue and thus it induced decrease in the clearance of triglyceride-rich lipoproteins [41]. Ultimately, abdominal obesity associated with insulin resistance and triglyceride may increase the uric acid level by the decreased insulin sensitivity (Fig. 1).

Bottom Line: In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level.High level of uric acid has been associated with metabolic syndrome, type 2 diabetes and cardiovascular diseases.Hyperuricemia has attributed to hyperinsulinemia in metabolic syndrome and decreased excretion of uric acid causing endothelial dysfunction in kidney leads to renal disease and cardiovascular disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju.

ABSTRACT
Recent studies have focused on hyperuricemia as a modulator for metabolic syndrome. Hyperuricemia has reported in many studies as a causal marker in a higher prevalence of metabolic syndrome. In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level. High level of uric acid has been associated with metabolic syndrome, type 2 diabetes and cardiovascular diseases. Hyperuricemia has attributed to hyperinsulinemia in metabolic syndrome and decreased excretion of uric acid causing endothelial dysfunction in kidney leads to renal disease and cardiovascular disorders. This review focus on the role of uric acid in the development of metabolic syndrome and onthe possible pathophysiology.

No MeSH data available.


Related in: MedlinePlus