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Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study.

Larsson N, Rankin GD, Bicer EM, Roos-Engstrand E, Pourazar J, Blomberg A, Mudway IS, Behndig AF - BMJ Open (2015)

Bottom Line: As secondary outcome measures, RTLF vitamin C concentration was measured and related to transporter expression, as well as bronchial epithelial inflammatory and goblet cells numbers.This experimental study is the first to demonstrate protein expression of GLUT2 and SVCT2 in the human bronchial epithelium.A negative correlation between SVCT2-positive goblet cells and bronchial RTLF vitamin C concentrations suggests a possible role for goblet cells in regulating the extracellular vitamin C pool.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine and Allergy, Umeå University, Umeå, Sweden.

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(A) Goblet cells in bronchial biopsies and total vitamin C concentrations in bronchial wash show a negative correlation (ρ=−0.842, p<0.01). (B) sodium-ascorbate cotransporters (SVCT2)+goblet cells in bronchial biopsies and total vitamin C concentrations in bronchial wash show a negative correlation (r=−0.661, p<0.05).
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BMJOPEN2014006979F3: (A) Goblet cells in bronchial biopsies and total vitamin C concentrations in bronchial wash show a negative correlation (ρ=−0.842, p<0.01). (B) sodium-ascorbate cotransporters (SVCT2)+goblet cells in bronchial biopsies and total vitamin C concentrations in bronchial wash show a negative correlation (r=−0.661, p<0.05).

Mentions: There was a negative correlation between total vitamin C concentration in the bronchial RTLFs and goblet cells in bronchial biopsies: ρ=−0.842, p<0.01. This negative correlation remained when only SVCT2-positive goblet cells were considered: ρ=−0.661, p<0.05 (figure 3). No other correlations were observed between the measured RTLF antioxidants with vitamin C transporters within the bronchial epithelium.


Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study.

Larsson N, Rankin GD, Bicer EM, Roos-Engstrand E, Pourazar J, Blomberg A, Mudway IS, Behndig AF - BMJ Open (2015)

(A) Goblet cells in bronchial biopsies and total vitamin C concentrations in bronchial wash show a negative correlation (ρ=−0.842, p<0.01). (B) sodium-ascorbate cotransporters (SVCT2)+goblet cells in bronchial biopsies and total vitamin C concentrations in bronchial wash show a negative correlation (r=−0.661, p<0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390727&req=5

BMJOPEN2014006979F3: (A) Goblet cells in bronchial biopsies and total vitamin C concentrations in bronchial wash show a negative correlation (ρ=−0.842, p<0.01). (B) sodium-ascorbate cotransporters (SVCT2)+goblet cells in bronchial biopsies and total vitamin C concentrations in bronchial wash show a negative correlation (r=−0.661, p<0.05).
Mentions: There was a negative correlation between total vitamin C concentration in the bronchial RTLFs and goblet cells in bronchial biopsies: ρ=−0.842, p<0.01. This negative correlation remained when only SVCT2-positive goblet cells were considered: ρ=−0.661, p<0.05 (figure 3). No other correlations were observed between the measured RTLF antioxidants with vitamin C transporters within the bronchial epithelium.

Bottom Line: As secondary outcome measures, RTLF vitamin C concentration was measured and related to transporter expression, as well as bronchial epithelial inflammatory and goblet cells numbers.This experimental study is the first to demonstrate protein expression of GLUT2 and SVCT2 in the human bronchial epithelium.A negative correlation between SVCT2-positive goblet cells and bronchial RTLF vitamin C concentrations suggests a possible role for goblet cells in regulating the extracellular vitamin C pool.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine and Allergy, Umeå University, Umeå, Sweden.

Show MeSH
Related in: MedlinePlus