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Prognostic role of the neutrophil-lymphocyte ratio in renal cell carcinoma: a meta-analysis.

Hu K, Lou L, Ye J, Zhang S - BMJ Open (2015)

Bottom Line: Our analysis results indicated that elevated NLR predicted poorer OS (HR=1.82, 95% CI 1.51 to 2.19) and RFS/PFS (HR=2.18, 95% CI 1.75 to 2.71) in patients with RCC.However, it differed significantly by assessment of the cut-off value defining 'elevated NLR' in RFS/PFS (p=0.004).NLR should be monitored in patients with RCC for rational risk stratification and treatment individualisation.

View Article: PubMed Central - PubMed

Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.

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Meta-analysis of the association between elevated NLR and RFS/PFS of RCC. Results are presented as individual and pooled HR and 95% CI (NLR, neutrophil-lymphocyte ratio; RCC, renal cell carcinoma, RFS/PFS, recurrence-free/progress-free survival).
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BMJOPEN2014006404F3: Meta-analysis of the association between elevated NLR and RFS/PFS of RCC. Results are presented as individual and pooled HR and 95% CI (NLR, neutrophil-lymphocyte ratio; RCC, renal cell carcinoma, RFS/PFS, recurrence-free/progress-free survival).

Mentions: There were 10 cohorts presenting the data of pretreatment NLR and RFS/PFS in patients with RCC. A significant relationship between elevated pretreatment NLR and shorter RFS/PFS (HR=2.18; 95% CI 1.75 to 2.71; p<0.001; figure 3) with non-significant heterogeneity (I2=25.0%; p=0.214) was detected according to our pooled estimates.


Prognostic role of the neutrophil-lymphocyte ratio in renal cell carcinoma: a meta-analysis.

Hu K, Lou L, Ye J, Zhang S - BMJ Open (2015)

Meta-analysis of the association between elevated NLR and RFS/PFS of RCC. Results are presented as individual and pooled HR and 95% CI (NLR, neutrophil-lymphocyte ratio; RCC, renal cell carcinoma, RFS/PFS, recurrence-free/progress-free survival).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390726&req=5

BMJOPEN2014006404F3: Meta-analysis of the association between elevated NLR and RFS/PFS of RCC. Results are presented as individual and pooled HR and 95% CI (NLR, neutrophil-lymphocyte ratio; RCC, renal cell carcinoma, RFS/PFS, recurrence-free/progress-free survival).
Mentions: There were 10 cohorts presenting the data of pretreatment NLR and RFS/PFS in patients with RCC. A significant relationship between elevated pretreatment NLR and shorter RFS/PFS (HR=2.18; 95% CI 1.75 to 2.71; p<0.001; figure 3) with non-significant heterogeneity (I2=25.0%; p=0.214) was detected according to our pooled estimates.

Bottom Line: Our analysis results indicated that elevated NLR predicted poorer OS (HR=1.82, 95% CI 1.51 to 2.19) and RFS/PFS (HR=2.18, 95% CI 1.75 to 2.71) in patients with RCC.However, it differed significantly by assessment of the cut-off value defining 'elevated NLR' in RFS/PFS (p=0.004).NLR should be monitored in patients with RCC for rational risk stratification and treatment individualisation.

View Article: PubMed Central - PubMed

Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.

Show MeSH
Related in: MedlinePlus