Prognostic role of the neutrophil-lymphocyte ratio in renal cell carcinoma: a meta-analysis.
Bottom Line: Our analysis results indicated that elevated NLR predicted poorer OS (HR=1.82, 95% CI 1.51 to 2.19) and RFS/PFS (HR=2.18, 95% CI 1.75 to 2.71) in patients with RCC.However, it differed significantly by assessment of the cut-off value defining 'elevated NLR' in RFS/PFS (p=0.004).NLR should be monitored in patients with RCC for rational risk stratification and treatment individualisation.
Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.Show MeSH
Related in: MedlinePlus
Mentions: There were 10 cohorts presenting the data of pretreatment NLR and RFS/PFS in patients with RCC. A significant relationship between elevated pretreatment NLR and shorter RFS/PFS (HR=2.18; 95% CI 1.75 to 2.71; p<0.001; figure 3) with non-significant heterogeneity (I2=25.0%; p=0.214) was detected according to our pooled estimates.
Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.