Prognostic role of the neutrophil-lymphocyte ratio in renal cell carcinoma: a meta-analysis.
Bottom Line: Our analysis results indicated that elevated NLR predicted poorer OS (HR=1.82, 95% CI 1.51 to 2.19) and RFS/PFS (HR=2.18, 95% CI 1.75 to 2.71) in patients with RCC.However, it differed significantly by assessment of the cut-off value defining 'elevated NLR' in RFS/PFS (p=0.004).NLR should be monitored in patients with RCC for rational risk stratification and treatment individualisation.
Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.Show MeSH
Related in: MedlinePlus
Mentions: There were 13 cohorts presenting the data of pretreatment NLR and OS in patients with RCC. Elevated NLR was significantly associated with shorter OS (HR=1.82; 95% CI 1.51 to 2.19; p<0.001; figure 2), but there was evidence of moderate heterogeneity between studies (I2=52.8%; p=0.013).
Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.