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Prognostic role of the neutrophil-lymphocyte ratio in renal cell carcinoma: a meta-analysis.

Hu K, Lou L, Ye J, Zhang S - BMJ Open (2015)

Bottom Line: Our analysis results indicated that elevated NLR predicted poorer OS (HR=1.82, 95% CI 1.51 to 2.19) and RFS/PFS (HR=2.18, 95% CI 1.75 to 2.71) in patients with RCC.However, it differed significantly by assessment of the cut-off value defining 'elevated NLR' in RFS/PFS (p=0.004).NLR should be monitored in patients with RCC for rational risk stratification and treatment individualisation.

View Article: PubMed Central - PubMed

Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.

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Related in: MedlinePlus

Flow chart of study selection process (CRP, C reactive protein; NLR, neutrophil–lymphocyte ratio; RCC, renal cell carcinoma).
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BMJOPEN2014006404F1: Flow chart of study selection process (CRP, C reactive protein; NLR, neutrophil–lymphocyte ratio; RCC, renal cell carcinoma).

Mentions: The initial search algorithm retrieved a total of 403 studies. After the title and abstract were reviewed, only 30 records were identified regarding the association of NLR and RCC (figure 1). After a full-text review, a total of 14 retrospective studies1216–28 (15 cohorts) with 3357 RCCs were included in our meta-analysis. The study by Hatakeyama et al28 reported the HR and 95% CI of two different cohorts separately. If the patients were overlapping or partially overlapping in several studies, only the study with the most complete data was included.


Prognostic role of the neutrophil-lymphocyte ratio in renal cell carcinoma: a meta-analysis.

Hu K, Lou L, Ye J, Zhang S - BMJ Open (2015)

Flow chart of study selection process (CRP, C reactive protein; NLR, neutrophil–lymphocyte ratio; RCC, renal cell carcinoma).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390726&req=5

BMJOPEN2014006404F1: Flow chart of study selection process (CRP, C reactive protein; NLR, neutrophil–lymphocyte ratio; RCC, renal cell carcinoma).
Mentions: The initial search algorithm retrieved a total of 403 studies. After the title and abstract were reviewed, only 30 records were identified regarding the association of NLR and RCC (figure 1). After a full-text review, a total of 14 retrospective studies1216–28 (15 cohorts) with 3357 RCCs were included in our meta-analysis. The study by Hatakeyama et al28 reported the HR and 95% CI of two different cohorts separately. If the patients were overlapping or partially overlapping in several studies, only the study with the most complete data was included.

Bottom Line: Our analysis results indicated that elevated NLR predicted poorer OS (HR=1.82, 95% CI 1.51 to 2.19) and RFS/PFS (HR=2.18, 95% CI 1.75 to 2.71) in patients with RCC.However, it differed significantly by assessment of the cut-off value defining 'elevated NLR' in RFS/PFS (p=0.004).NLR should be monitored in patients with RCC for rational risk stratification and treatment individualisation.

View Article: PubMed Central - PubMed

Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.

Show MeSH
Related in: MedlinePlus