Prognostic role of the neutrophil-lymphocyte ratio in renal cell carcinoma: a meta-analysis.
Bottom Line: Our analysis results indicated that elevated NLR predicted poorer OS (HR=1.82, 95% CI 1.51 to 2.19) and RFS/PFS (HR=2.18, 95% CI 1.75 to 2.71) in patients with RCC.However, it differed significantly by assessment of the cut-off value defining 'elevated NLR' in RFS/PFS (p=0.004).NLR should be monitored in patients with RCC for rational risk stratification and treatment individualisation.
Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.Show MeSH
Related in: MedlinePlus
Mentions: The initial search algorithm retrieved a total of 403 studies. After the title and abstract were reviewed, only 30 records were identified regarding the association of NLR and RCC (figure 1). After a full-text review, a total of 14 retrospective studies1216–28 (15 cohorts) with 3357 RCCs were included in our meta-analysis. The study by Hatakeyama et al28 reported the HR and 95% CI of two different cohorts separately. If the patients were overlapping or partially overlapping in several studies, only the study with the most complete data was included.
Affiliation: Cancer Institute, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.