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Impact of cardiovascular risk factors and medication use on the efficacy of remote ischaemic conditioning: post hoc subgroup analysis of a randomised controlled trial.

Sloth AD, Schmidt MR, Munk K, Schmidt M, Pedersen L, Sørensen HT, Bøtker HE, CONDI Investigato - BMJ Open (2015)

Bottom Line: The effect of RIC may be modified by cardiovascular risk factors and their medications.We found no significant difference in the efficacy of RIC in subgroups of cardiovascular risk factors, lipid and glucose levels, and medication use.However, point estimates indicated a reduced effect of RIC among smokers (median difference in MSI between RIC and control groups: -0.02 (95% CI -0.32 to 0.28) in smokers vs 0.25 (95% CI 0.08 to 0.42) in non-smokers, p value for interaction=0.13) and an increased effect of RIC in statin users (median difference in MSI between RIC and control groups: 0.34 (95% CI 0.03 to 0.65) in statin users vs 0.09 (95% CI -0.11 to 0.29) in non-statin users, p value for interaction=0.19).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.

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Related in: MedlinePlus

Study flow chart. Grey boxes represent study population eligible for stratified analysis (n=139). AAR, area-at-risk; ARBs, angiotensin II receptor blockers; FIS, final infarct size; HbA1c, glycated haemoglobin; LDL, low-density lipoprotein; MSI, myocardial salvage index; pPCI, primary percutaneous coronary intervention; RIC, remote ischaemic conditioning; STEMI, ST-elevation myocardial infarction.
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BMJOPEN2014006923F1: Study flow chart. Grey boxes represent study population eligible for stratified analysis (n=139). AAR, area-at-risk; ARBs, angiotensin II receptor blockers; FIS, final infarct size; HbA1c, glycated haemoglobin; LDL, low-density lipoprotein; MSI, myocardial salvage index; pPCI, primary percutaneous coronary intervention; RIC, remote ischaemic conditioning; STEMI, ST-elevation myocardial infarction.

Mentions: The study flow chart is shown in figure 1. A total of 333 patients with suspected STEMI were randomly assigned to either RIC as an adjunct to pPCI (n=166) or to standard treatment with pPCI alone (n=167). Eighty-two patients were excluded during hospital admission, because they did not meet the trial criteria (34 with an unconfirmed diagnosis of STEMI, 41 with previous myocardial infarction, 4 with previous CABG and 3 with chest pain >12 h before admission).


Impact of cardiovascular risk factors and medication use on the efficacy of remote ischaemic conditioning: post hoc subgroup analysis of a randomised controlled trial.

Sloth AD, Schmidt MR, Munk K, Schmidt M, Pedersen L, Sørensen HT, Bøtker HE, CONDI Investigato - BMJ Open (2015)

Study flow chart. Grey boxes represent study population eligible for stratified analysis (n=139). AAR, area-at-risk; ARBs, angiotensin II receptor blockers; FIS, final infarct size; HbA1c, glycated haemoglobin; LDL, low-density lipoprotein; MSI, myocardial salvage index; pPCI, primary percutaneous coronary intervention; RIC, remote ischaemic conditioning; STEMI, ST-elevation myocardial infarction.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390720&req=5

BMJOPEN2014006923F1: Study flow chart. Grey boxes represent study population eligible for stratified analysis (n=139). AAR, area-at-risk; ARBs, angiotensin II receptor blockers; FIS, final infarct size; HbA1c, glycated haemoglobin; LDL, low-density lipoprotein; MSI, myocardial salvage index; pPCI, primary percutaneous coronary intervention; RIC, remote ischaemic conditioning; STEMI, ST-elevation myocardial infarction.
Mentions: The study flow chart is shown in figure 1. A total of 333 patients with suspected STEMI were randomly assigned to either RIC as an adjunct to pPCI (n=166) or to standard treatment with pPCI alone (n=167). Eighty-two patients were excluded during hospital admission, because they did not meet the trial criteria (34 with an unconfirmed diagnosis of STEMI, 41 with previous myocardial infarction, 4 with previous CABG and 3 with chest pain >12 h before admission).

Bottom Line: The effect of RIC may be modified by cardiovascular risk factors and their medications.We found no significant difference in the efficacy of RIC in subgroups of cardiovascular risk factors, lipid and glucose levels, and medication use.However, point estimates indicated a reduced effect of RIC among smokers (median difference in MSI between RIC and control groups: -0.02 (95% CI -0.32 to 0.28) in smokers vs 0.25 (95% CI 0.08 to 0.42) in non-smokers, p value for interaction=0.13) and an increased effect of RIC in statin users (median difference in MSI between RIC and control groups: 0.34 (95% CI 0.03 to 0.65) in statin users vs 0.09 (95% CI -0.11 to 0.29) in non-statin users, p value for interaction=0.19).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.

Show MeSH
Related in: MedlinePlus