Impact of cardiovascular risk factors and medication use on the efficacy of remote ischaemic conditioning: post hoc subgroup analysis of a randomised controlled trial.
Bottom Line: The effect of RIC may be modified by cardiovascular risk factors and their medications.We found no significant difference in the efficacy of RIC in subgroups of cardiovascular risk factors, lipid and glucose levels, and medication use.However, point estimates indicated a reduced effect of RIC among smokers (median difference in MSI between RIC and control groups: -0.02 (95% CI -0.32 to 0.28) in smokers vs 0.25 (95% CI 0.08 to 0.42) in non-smokers, p value for interaction=0.13) and an increased effect of RIC in statin users (median difference in MSI between RIC and control groups: 0.34 (95% CI 0.03 to 0.65) in statin users vs 0.09 (95% CI -0.11 to 0.29) in non-statin users, p value for interaction=0.19).
Affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.Show MeSH
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Mentions: The study flow chart is shown in figure 1. A total of 333 patients with suspected STEMI were randomly assigned to either RIC as an adjunct to pPCI (n=166) or to standard treatment with pPCI alone (n=167). Eighty-two patients were excluded during hospital admission, because they did not meet the trial criteria (34 with an unconfirmed diagnosis of STEMI, 41 with previous myocardial infarction, 4 with previous CABG and 3 with chest pain >12 h before admission).
Affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.