Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.
Bottom Line: Significant benefit was also seen with the Alzheimer's disease Assessment Scale-Cognition (ADAS-Cog) (g=-0.26, 95% CI -0.445 to -0.08; p=0.005).There was no evidence that CT or MCTS produced significant improvements on general cognition outcomes and not enough CR studies for meta-analysis.Additionally, 95% prediction intervals suggested that although statistically significant, CS may not lead to benefits on the ADAS-Cog in all clinical settings.
Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.Show MeSH
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Mentions: On the ADAS-Cog there was a significant pooled effect size favouring CS of −0.26 (95% CI −0.44 to −0.08; z=2.82, p=0.005, figure 4). There was low heterogeneity between the nine studies (I2=18.5), however, 95% prediction intervals (−0.62 to 0.10) suggested that the intervention may not be beneficial in individual settings. There were no studies comparing CS to active controls that used the ADAS-Cog as an outcome measure.
Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.