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Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.

Huntley JD, Gould RL, Liu K, Smith M, Howard RJ - BMJ Open (2015)

Bottom Line: Significant benefit was also seen with the Alzheimer's disease Assessment Scale-Cognition (ADAS-Cog) (g=-0.26, 95% CI -0.445 to -0.08; p=0.005).There was no evidence that CT or MCTS produced significant improvements on general cognition outcomes and not enough CR studies for meta-analysis.Additionally, 95% prediction intervals suggested that although statistically significant, CS may not lead to benefits on the ADAS-Cog in all clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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Related in: MedlinePlus

Forest Plot of CS versus non-active controls-ADAS-Cog outcome. ADAS-Cog, Alzheimer's disease Assessment Scale-cognitive subscale; CS, cognitive stimulation.
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BMJOPEN2014005247F4: Forest Plot of CS versus non-active controls-ADAS-Cog outcome. ADAS-Cog, Alzheimer's disease Assessment Scale-cognitive subscale; CS, cognitive stimulation.

Mentions: On the ADAS-Cog there was a significant pooled effect size favouring CS of −0.26 (95% CI −0.44 to −0.08; z=2.82, p=0.005, figure 4). There was low heterogeneity between the nine studies (I2=18.5), however, 95% prediction intervals (−0.62 to 0.10) suggested that the intervention may not be beneficial in individual settings. There were no studies comparing CS to active controls that used the ADAS-Cog as an outcome measure.


Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.

Huntley JD, Gould RL, Liu K, Smith M, Howard RJ - BMJ Open (2015)

Forest Plot of CS versus non-active controls-ADAS-Cog outcome. ADAS-Cog, Alzheimer's disease Assessment Scale-cognitive subscale; CS, cognitive stimulation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390716&req=5

BMJOPEN2014005247F4: Forest Plot of CS versus non-active controls-ADAS-Cog outcome. ADAS-Cog, Alzheimer's disease Assessment Scale-cognitive subscale; CS, cognitive stimulation.
Mentions: On the ADAS-Cog there was a significant pooled effect size favouring CS of −0.26 (95% CI −0.44 to −0.08; z=2.82, p=0.005, figure 4). There was low heterogeneity between the nine studies (I2=18.5), however, 95% prediction intervals (−0.62 to 0.10) suggested that the intervention may not be beneficial in individual settings. There were no studies comparing CS to active controls that used the ADAS-Cog as an outcome measure.

Bottom Line: Significant benefit was also seen with the Alzheimer's disease Assessment Scale-Cognition (ADAS-Cog) (g=-0.26, 95% CI -0.445 to -0.08; p=0.005).There was no evidence that CT or MCTS produced significant improvements on general cognition outcomes and not enough CR studies for meta-analysis.Additionally, 95% prediction intervals suggested that although statistically significant, CS may not lead to benefits on the ADAS-Cog in all clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Show MeSH
Related in: MedlinePlus