Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.
Bottom Line: Significant benefit was also seen with the Alzheimer's disease Assessment Scale-Cognition (ADAS-Cog) (g=-0.26, 95% CI -0.445 to -0.08; p=0.005).There was no evidence that CT or MCTS produced significant improvements on general cognition outcomes and not enough CR studies for meta-analysis.Additionally, 95% prediction intervals suggested that although statistically significant, CS may not lead to benefits on the ADAS-Cog in all clinical settings.
Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.Show MeSH
Related in: MedlinePlus
Mentions: A smaller but still significant pooled effect size of 0.35 (95% CI 0.06 to 0.64; z=2.34, p=0.019) was found for CS versus active controls on the MMSE (figure 3), with no heterogeneity between the three studies (I2=0.0%).
Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.