Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.
Bottom Line: Significant benefit was also seen with the Alzheimer's disease Assessment Scale-Cognition (ADAS-Cog) (g=-0.26, 95% CI -0.445 to -0.08; p=0.005).There was no evidence that CT or MCTS produced significant improvements on general cognition outcomes and not enough CR studies for meta-analysis.Additionally, 95% prediction intervals suggested that although statistically significant, CS may not lead to benefits on the ADAS-Cog in all clinical settings.
Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.Show MeSH
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Mentions: The results of all meta-analyses conducted are presented in table 3. Postintervention, there was a significant pooled effect size for CS versus non-active controls on the MMSE (g=0.51, 95% CI 0.35 to 0.66, z=6.23, p<0.001, figure 2). There was low heterogeneity between studies (I2=24.9%). The calculated 95% prediction interval (0.124 to 0.89) suggested that the intervention was beneficial in individual settings.
Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.