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Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.

Huntley JD, Gould RL, Liu K, Smith M, Howard RJ - BMJ Open (2015)

Bottom Line: Significant benefit was also seen with the Alzheimer's disease Assessment Scale-Cognition (ADAS-Cog) (g=-0.26, 95% CI -0.445 to -0.08; p=0.005).There was no evidence that CT or MCTS produced significant improvements on general cognition outcomes and not enough CR studies for meta-analysis.Additionally, 95% prediction intervals suggested that although statistically significant, CS may not lead to benefits on the ADAS-Cog in all clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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Related in: MedlinePlus

Forest Plot of CS versus non-active controls-MMSE outcome. CS, cognitive stimulation; MMSE, mini-mental state examination.
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BMJOPEN2014005247F2: Forest Plot of CS versus non-active controls-MMSE outcome. CS, cognitive stimulation; MMSE, mini-mental state examination.

Mentions: The results of all meta-analyses conducted are presented in table 3. Postintervention, there was a significant pooled effect size for CS versus non-active controls on the MMSE (g=0.51, 95% CI 0.35 to 0.66, z=6.23, p<0.001, figure 2). There was low heterogeneity between studies (I2=24.9%). The calculated 95% prediction interval (0.124 to 0.89) suggested that the intervention was beneficial in individual settings.


Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.

Huntley JD, Gould RL, Liu K, Smith M, Howard RJ - BMJ Open (2015)

Forest Plot of CS versus non-active controls-MMSE outcome. CS, cognitive stimulation; MMSE, mini-mental state examination.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390716&req=5

BMJOPEN2014005247F2: Forest Plot of CS versus non-active controls-MMSE outcome. CS, cognitive stimulation; MMSE, mini-mental state examination.
Mentions: The results of all meta-analyses conducted are presented in table 3. Postintervention, there was a significant pooled effect size for CS versus non-active controls on the MMSE (g=0.51, 95% CI 0.35 to 0.66, z=6.23, p<0.001, figure 2). There was low heterogeneity between studies (I2=24.9%). The calculated 95% prediction interval (0.124 to 0.89) suggested that the intervention was beneficial in individual settings.

Bottom Line: Significant benefit was also seen with the Alzheimer's disease Assessment Scale-Cognition (ADAS-Cog) (g=-0.26, 95% CI -0.445 to -0.08; p=0.005).There was no evidence that CT or MCTS produced significant improvements on general cognition outcomes and not enough CR studies for meta-analysis.Additionally, 95% prediction intervals suggested that although statistically significant, CS may not lead to benefits on the ADAS-Cog in all clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Show MeSH
Related in: MedlinePlus