Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.
Bottom Line: Significant benefit was also seen with the Alzheimer's disease Assessment Scale-Cognition (ADAS-Cog) (g=-0.26, 95% CI -0.445 to -0.08; p=0.005).There was no evidence that CT or MCTS produced significant improvements on general cognition outcomes and not enough CR studies for meta-analysis.Additionally, 95% prediction intervals suggested that although statistically significant, CS may not lead to benefits on the ADAS-Cog in all clinical settings.
Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.Show MeSH
Related in: MedlinePlus
Mentions: Literature searches identified 2206 potential studies, 59 of which met inclusion criteria for data extraction (PRISMA flow diagram, figure 1 and PRISMA checklist, online supplementary table S1). Of these, 33 contained general cognition outcome measures that could be included in meta-analyses and were selected.16–48 Summary characteristics of these studies are presented in online supplementary table S2.
Affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.