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Meta-Analysis of the SLCO1B1 c.521T>C Variant Reveals Slight Influence on the Lipid-Lowering Efficacy of Statins.

Dou Y, Zhu X, Wang Q, Tian X, Cheng J, Zhang E - Ann Lab Med (2015)

Bottom Line: The effects of statins show significant variability between individuals.Furthermore, there was no significant effect in the meta-analyses of the variant heterozygote, homozygote, and Chinese populations.Subgroup meta-analysis indicated that the time required for the statin to take effect did not significantly affect the association between lipid-lowering efficacy of statins and SLCO1B1 c.521T>C polymorphism.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College, Zibo, China.

ABSTRACT

Background: Several studies have focused on the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism; however, the results are conflicting. The effects of statins show significant variability between individuals. This meta-analysis aimed to investigate the effects of the SLCO1B1 c.521T>C polymorphism on the lipid-lowering effects of statins.

Methods: We systematically searched PubMed and Web of Science to screen relevant studies. Meta-analysis was performed to identify the association between SLCO1B1 c.521 polymorphisms and the lipid-lowering effects of statins on the basis of the standard mean difference (SMD) and 95% confidence intervals (CIs). Additionally, we checked for heterogeneity (I(2)) among studies and evidence of publication bias. We obtained eight studies including 2,012 wild genotype (T/T) and 526 variant genotype (T/C and C/C) cases.

Results: No significant difference was observed in the lipid-lowering efficacy of statins between the wild and variant genotypes of SLCO1B1, with a pooled SMD of 0.03 (95% CI: -0.07-0.13). Furthermore, there was no significant effect in the meta-analyses of the variant heterozygote, homozygote, and Chinese populations. Subgroup meta-analysis indicated that the time required for the statin to take effect did not significantly affect the association between lipid-lowering efficacy of statins and SLCO1B1 c.521T>C polymorphism. However, the wild genotype improved the lipid-lowering efficacy of simvastatin with a pooled SMD of -0.26 (95% CI: -0.47- -0.05).

Conclusions: No significant association was detected between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism, with the exception of simvastatin.

No MeSH data available.


Forest plots and funnel plots of each subgroup. (A) Forest plots of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism of Chinese populations, and funnel plot for evaluating publication bias; (B) Forest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C heterozygous genotype, and funnel plot for evaluating publication bias; (C) Forest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C homozygote genotype, and funnel plotfor evaluating publication bias; (D) Forrest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C variant genotypes (T/C and C/C genotype), and funnel plot for evaluating publication bias. *TC genotype; †CC genotype; *†TC and CC genotype; S: simvastatin; A: atorvastatin; R: rosuvastatin; 4: 4 weeks; 8: 8 weeks.Abbreviations: SMD, standard mean difference; CI, confidence interval; df, degrees of freedom.
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Figure 3: Forest plots and funnel plots of each subgroup. (A) Forest plots of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism of Chinese populations, and funnel plot for evaluating publication bias; (B) Forest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C heterozygous genotype, and funnel plot for evaluating publication bias; (C) Forest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C homozygote genotype, and funnel plotfor evaluating publication bias; (D) Forrest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C variant genotypes (T/C and C/C genotype), and funnel plot for evaluating publication bias. *TC genotype; †CC genotype; *†TC and CC genotype; S: simvastatin; A: atorvastatin; R: rosuvastatin; 4: 4 weeks; 8: 8 weeks.Abbreviations: SMD, standard mean difference; CI, confidence interval; df, degrees of freedom.

Mentions: We observed no obvious heterogeneity (I2=31%) among the eight studies that evaluated the lipid-lowering efficacy of statins between the wild and variant genotypes, based on a change inLDL-cholesterol concentration (Fig. 2). Accordingly, the FE model was used to calculate the pooled SMDs with corresponding 95% CIs. Overall, the meta-analysis results indicated that there was nostatistically significant association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism. The overall SMD was 0.03 (95% CI: -0.07-0.13; P=0.59). When stratifying among the Chinese population specifically, we obtained an SMD of 0.03 (95% CI: -0.15-0.21; P=0.74) and inconsistent coefficients, indicating moderate heterogeneity (I2=49%; Fig. 3A). We found no significant association in the stratified analyses according to the Chinese population sample size.


Meta-Analysis of the SLCO1B1 c.521T>C Variant Reveals Slight Influence on the Lipid-Lowering Efficacy of Statins.

Dou Y, Zhu X, Wang Q, Tian X, Cheng J, Zhang E - Ann Lab Med (2015)

Forest plots and funnel plots of each subgroup. (A) Forest plots of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism of Chinese populations, and funnel plot for evaluating publication bias; (B) Forest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C heterozygous genotype, and funnel plot for evaluating publication bias; (C) Forest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C homozygote genotype, and funnel plotfor evaluating publication bias; (D) Forrest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C variant genotypes (T/C and C/C genotype), and funnel plot for evaluating publication bias. *TC genotype; †CC genotype; *†TC and CC genotype; S: simvastatin; A: atorvastatin; R: rosuvastatin; 4: 4 weeks; 8: 8 weeks.Abbreviations: SMD, standard mean difference; CI, confidence interval; df, degrees of freedom.
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Related In: Results  -  Collection

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Figure 3: Forest plots and funnel plots of each subgroup. (A) Forest plots of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism of Chinese populations, and funnel plot for evaluating publication bias; (B) Forest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C heterozygous genotype, and funnel plot for evaluating publication bias; (C) Forest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C homozygote genotype, and funnel plotfor evaluating publication bias; (D) Forrest plot of SMD for the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C variant genotypes (T/C and C/C genotype), and funnel plot for evaluating publication bias. *TC genotype; †CC genotype; *†TC and CC genotype; S: simvastatin; A: atorvastatin; R: rosuvastatin; 4: 4 weeks; 8: 8 weeks.Abbreviations: SMD, standard mean difference; CI, confidence interval; df, degrees of freedom.
Mentions: We observed no obvious heterogeneity (I2=31%) among the eight studies that evaluated the lipid-lowering efficacy of statins between the wild and variant genotypes, based on a change inLDL-cholesterol concentration (Fig. 2). Accordingly, the FE model was used to calculate the pooled SMDs with corresponding 95% CIs. Overall, the meta-analysis results indicated that there was nostatistically significant association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism. The overall SMD was 0.03 (95% CI: -0.07-0.13; P=0.59). When stratifying among the Chinese population specifically, we obtained an SMD of 0.03 (95% CI: -0.15-0.21; P=0.74) and inconsistent coefficients, indicating moderate heterogeneity (I2=49%; Fig. 3A). We found no significant association in the stratified analyses according to the Chinese population sample size.

Bottom Line: The effects of statins show significant variability between individuals.Furthermore, there was no significant effect in the meta-analyses of the variant heterozygote, homozygote, and Chinese populations.Subgroup meta-analysis indicated that the time required for the statin to take effect did not significantly affect the association between lipid-lowering efficacy of statins and SLCO1B1 c.521T>C polymorphism.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College, Zibo, China.

ABSTRACT

Background: Several studies have focused on the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism; however, the results are conflicting. The effects of statins show significant variability between individuals. This meta-analysis aimed to investigate the effects of the SLCO1B1 c.521T>C polymorphism on the lipid-lowering effects of statins.

Methods: We systematically searched PubMed and Web of Science to screen relevant studies. Meta-analysis was performed to identify the association between SLCO1B1 c.521 polymorphisms and the lipid-lowering effects of statins on the basis of the standard mean difference (SMD) and 95% confidence intervals (CIs). Additionally, we checked for heterogeneity (I(2)) among studies and evidence of publication bias. We obtained eight studies including 2,012 wild genotype (T/T) and 526 variant genotype (T/C and C/C) cases.

Results: No significant difference was observed in the lipid-lowering efficacy of statins between the wild and variant genotypes of SLCO1B1, with a pooled SMD of 0.03 (95% CI: -0.07-0.13). Furthermore, there was no significant effect in the meta-analyses of the variant heterozygote, homozygote, and Chinese populations. Subgroup meta-analysis indicated that the time required for the statin to take effect did not significantly affect the association between lipid-lowering efficacy of statins and SLCO1B1 c.521T>C polymorphism. However, the wild genotype improved the lipid-lowering efficacy of simvastatin with a pooled SMD of -0.26 (95% CI: -0.47- -0.05).

Conclusions: No significant association was detected between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism, with the exception of simvastatin.

No MeSH data available.