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Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis.

Martínez MA, Olsson B, Bau L, Matas E, Cobo Calvo Á, Andreasson U, Blennow K, Romero-Pinel L, Martínez-Yélamos S, Zetterberg H - Mult. Scler. (2015)

Bottom Line: The mean follow-up time of these 301 patients was 11.7 ± 6.4 years.High levels of NFL were associated with early conversion from CIS to CDMS (hazard ratio (HR) with 95% confidence interval (CI): 2.69 (1.75 - 4.15); p < 0.0001).CSF levels of NFL in CIS patients are an independent prognostic marker for conversion to CDMS.

View Article: PubMed Central - PubMed

Affiliation: Joan XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain/Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain amane.hj23.ics@gencat.cat.

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YKL-40 levels and disability progression in the relapsing forms of MS.We used a Kaplan-Meier estimator to assess the time to reach EDSS 6. The median of CSF biomarker levels (YKL-40 = 101 ng/mL) in relapsing-remitting forms (CIS and RRMS) group (n = 301) was established as the cut-off value to classify MS patients into two groups (high or low), respectively. Mean survival time in years (y) with 95%CI are displayed. The time to reach EDSS 6 was significantly shorter in patients with high levels of YKL-40 (n = 140), compared with patients with low levels of YKL-40 (n = 140).aBecause YKL-40 was the last biomarker to be analyzed, 21 samples did not have enough volume left for the analysis.CIS: clinically-isolated syndrome; CSF: Cerebrospinal fluid; EDSS: Expanded Disability Status Scale; MS: multiple sclerosis; RRMS: relapsing–remitting MS; y: years; YKL-40: human chitinase 3-like 1 protein
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fig3-1352458514549397: YKL-40 levels and disability progression in the relapsing forms of MS.We used a Kaplan-Meier estimator to assess the time to reach EDSS 6. The median of CSF biomarker levels (YKL-40 = 101 ng/mL) in relapsing-remitting forms (CIS and RRMS) group (n = 301) was established as the cut-off value to classify MS patients into two groups (high or low), respectively. Mean survival time in years (y) with 95%CI are displayed. The time to reach EDSS 6 was significantly shorter in patients with high levels of YKL-40 (n = 140), compared with patients with low levels of YKL-40 (n = 140).aBecause YKL-40 was the last biomarker to be analyzed, 21 samples did not have enough volume left for the analysis.CIS: clinically-isolated syndrome; CSF: Cerebrospinal fluid; EDSS: Expanded Disability Status Scale; MS: multiple sclerosis; RRMS: relapsing–remitting MS; y: years; YKL-40: human chitinase 3-like 1 protein

Mentions: We also investigated CSF biomarker levels in CIS and RRMS patients, in relation to disability progression. Survival analyses were performed to evaluate the association of CSF biomarker levels and demographic variables with the period of time to reach EDSS 3 and EDSS 6. Univariate analysis showed that EDSS at LP > 2.0 and levels of GFAP, YKL-40 and MCP-1 were associated with the time to reach EDSS 3 (Table 4). Independently of basal EDSS > 2.0 (HR (95% CI): 3.42 (2.03 – 5.78); p < 0.0001), the Cox Hazard regression model showed that high levels of YKL-40 (2.78 (1.48 – 5.23); p = 0.001) and GFAP (1.83 (1.01 – 3.35); p = 0.04) were independently associated with earlier progression to EDSS 3 (Figure 2(a) and Figure 2(b)). Univariate analysis showed that gender, OCB, EDSS at LP > 2.0, and levels of GFAP, YKL-40 and MCP-1 were also associated with the time to reach EDSS 6 (Table 4). The Cox Hazard regression model showed that male gender (female gender HR (95% CI): 0.29 (0.09 – 0.99); p = 0.04) and high levels of YKL-40 (4.57 (1.01 – 20.83); p = 0.05) were independent risk factors to reach EDSS 6 (Figure 3).


Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis.

Martínez MA, Olsson B, Bau L, Matas E, Cobo Calvo Á, Andreasson U, Blennow K, Romero-Pinel L, Martínez-Yélamos S, Zetterberg H - Mult. Scler. (2015)

YKL-40 levels and disability progression in the relapsing forms of MS.We used a Kaplan-Meier estimator to assess the time to reach EDSS 6. The median of CSF biomarker levels (YKL-40 = 101 ng/mL) in relapsing-remitting forms (CIS and RRMS) group (n = 301) was established as the cut-off value to classify MS patients into two groups (high or low), respectively. Mean survival time in years (y) with 95%CI are displayed. The time to reach EDSS 6 was significantly shorter in patients with high levels of YKL-40 (n = 140), compared with patients with low levels of YKL-40 (n = 140).aBecause YKL-40 was the last biomarker to be analyzed, 21 samples did not have enough volume left for the analysis.CIS: clinically-isolated syndrome; CSF: Cerebrospinal fluid; EDSS: Expanded Disability Status Scale; MS: multiple sclerosis; RRMS: relapsing–remitting MS; y: years; YKL-40: human chitinase 3-like 1 protein
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4390605&req=5

fig3-1352458514549397: YKL-40 levels and disability progression in the relapsing forms of MS.We used a Kaplan-Meier estimator to assess the time to reach EDSS 6. The median of CSF biomarker levels (YKL-40 = 101 ng/mL) in relapsing-remitting forms (CIS and RRMS) group (n = 301) was established as the cut-off value to classify MS patients into two groups (high or low), respectively. Mean survival time in years (y) with 95%CI are displayed. The time to reach EDSS 6 was significantly shorter in patients with high levels of YKL-40 (n = 140), compared with patients with low levels of YKL-40 (n = 140).aBecause YKL-40 was the last biomarker to be analyzed, 21 samples did not have enough volume left for the analysis.CIS: clinically-isolated syndrome; CSF: Cerebrospinal fluid; EDSS: Expanded Disability Status Scale; MS: multiple sclerosis; RRMS: relapsing–remitting MS; y: years; YKL-40: human chitinase 3-like 1 protein
Mentions: We also investigated CSF biomarker levels in CIS and RRMS patients, in relation to disability progression. Survival analyses were performed to evaluate the association of CSF biomarker levels and demographic variables with the period of time to reach EDSS 3 and EDSS 6. Univariate analysis showed that EDSS at LP > 2.0 and levels of GFAP, YKL-40 and MCP-1 were associated with the time to reach EDSS 3 (Table 4). Independently of basal EDSS > 2.0 (HR (95% CI): 3.42 (2.03 – 5.78); p < 0.0001), the Cox Hazard regression model showed that high levels of YKL-40 (2.78 (1.48 – 5.23); p = 0.001) and GFAP (1.83 (1.01 – 3.35); p = 0.04) were independently associated with earlier progression to EDSS 3 (Figure 2(a) and Figure 2(b)). Univariate analysis showed that gender, OCB, EDSS at LP > 2.0, and levels of GFAP, YKL-40 and MCP-1 were also associated with the time to reach EDSS 6 (Table 4). The Cox Hazard regression model showed that male gender (female gender HR (95% CI): 0.29 (0.09 – 0.99); p = 0.04) and high levels of YKL-40 (4.57 (1.01 – 20.83); p = 0.05) were independent risk factors to reach EDSS 6 (Figure 3).

Bottom Line: The mean follow-up time of these 301 patients was 11.7 ± 6.4 years.High levels of NFL were associated with early conversion from CIS to CDMS (hazard ratio (HR) with 95% confidence interval (CI): 2.69 (1.75 - 4.15); p < 0.0001).CSF levels of NFL in CIS patients are an independent prognostic marker for conversion to CDMS.

View Article: PubMed Central - PubMed

Affiliation: Joan XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain/Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain amane.hj23.ics@gencat.cat.

Show MeSH
Related in: MedlinePlus