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Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis.

Martínez MA, Olsson B, Bau L, Matas E, Cobo Calvo Á, Andreasson U, Blennow K, Romero-Pinel L, Martínez-Yélamos S, Zetterberg H - Mult. Scler. (2015)

Bottom Line: The mean follow-up time of these 301 patients was 11.7 ± 6.4 years.High levels of NFL were associated with early conversion from CIS to CDMS (hazard ratio (HR) with 95% confidence interval (CI): 2.69 (1.75 - 4.15); p < 0.0001).CSF levels of NFL in CIS patients are an independent prognostic marker for conversion to CDMS.

View Article: PubMed Central - PubMed

Affiliation: Joan XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain/Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain amane.hj23.ics@gencat.cat.

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NFL levels and conversion from CIS to CDMS.The Kaplan-Meier estimator was used to assess the time to develop CDMS. The median of CSF biomarker levels (NFL = 1150 ng/L) in the CIS group (n = 109) was established as the cut-off value, and used to classify CIS patients into two groups (high or low), respectively. The graph represents the survival distribution function in patients with high levels of NFL (n = 53) and low levels of NFL (n = 50). We display the median time to CDMS in years (with 95% CI).CDMS: Clinically-definite multiple sclerosis; CIS: clinically-isolated syndrome; MS: multiple sclerosis; NFL: neurofilament light protein; y: year/s
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fig1-1352458514549397: NFL levels and conversion from CIS to CDMS.The Kaplan-Meier estimator was used to assess the time to develop CDMS. The median of CSF biomarker levels (NFL = 1150 ng/L) in the CIS group (n = 109) was established as the cut-off value, and used to classify CIS patients into two groups (high or low), respectively. The graph represents the survival distribution function in patients with high levels of NFL (n = 53) and low levels of NFL (n = 50). We display the median time to CDMS in years (with 95% CI).CDMS: Clinically-definite multiple sclerosis; CIS: clinically-isolated syndrome; MS: multiple sclerosis; NFL: neurofilament light protein; y: year/s

Mentions: We performed survival analyses to evaluate the association of CSF biomarker levels and demographic variables, with the time to conversion from CIS to CDMS. Univariate analysis showed that disease duration at LP, NFL levels and β-sAPP levels were associated with the time from CIS to CDMS (Table 4). A Cox hazard regression model showed that only CIS patients with increased CSF levels of NFL were associated with earlier conversion to CDMS (HR (95% CI): 2.69 (1.75 – 4.15); p < 0.0001) (Figure 1).


Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis.

Martínez MA, Olsson B, Bau L, Matas E, Cobo Calvo Á, Andreasson U, Blennow K, Romero-Pinel L, Martínez-Yélamos S, Zetterberg H - Mult. Scler. (2015)

NFL levels and conversion from CIS to CDMS.The Kaplan-Meier estimator was used to assess the time to develop CDMS. The median of CSF biomarker levels (NFL = 1150 ng/L) in the CIS group (n = 109) was established as the cut-off value, and used to classify CIS patients into two groups (high or low), respectively. The graph represents the survival distribution function in patients with high levels of NFL (n = 53) and low levels of NFL (n = 50). We display the median time to CDMS in years (with 95% CI).CDMS: Clinically-definite multiple sclerosis; CIS: clinically-isolated syndrome; MS: multiple sclerosis; NFL: neurofilament light protein; y: year/s
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4390605&req=5

fig1-1352458514549397: NFL levels and conversion from CIS to CDMS.The Kaplan-Meier estimator was used to assess the time to develop CDMS. The median of CSF biomarker levels (NFL = 1150 ng/L) in the CIS group (n = 109) was established as the cut-off value, and used to classify CIS patients into two groups (high or low), respectively. The graph represents the survival distribution function in patients with high levels of NFL (n = 53) and low levels of NFL (n = 50). We display the median time to CDMS in years (with 95% CI).CDMS: Clinically-definite multiple sclerosis; CIS: clinically-isolated syndrome; MS: multiple sclerosis; NFL: neurofilament light protein; y: year/s
Mentions: We performed survival analyses to evaluate the association of CSF biomarker levels and demographic variables, with the time to conversion from CIS to CDMS. Univariate analysis showed that disease duration at LP, NFL levels and β-sAPP levels were associated with the time from CIS to CDMS (Table 4). A Cox hazard regression model showed that only CIS patients with increased CSF levels of NFL were associated with earlier conversion to CDMS (HR (95% CI): 2.69 (1.75 – 4.15); p < 0.0001) (Figure 1).

Bottom Line: The mean follow-up time of these 301 patients was 11.7 ± 6.4 years.High levels of NFL were associated with early conversion from CIS to CDMS (hazard ratio (HR) with 95% confidence interval (CI): 2.69 (1.75 - 4.15); p < 0.0001).CSF levels of NFL in CIS patients are an independent prognostic marker for conversion to CDMS.

View Article: PubMed Central - PubMed

Affiliation: Joan XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain/Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain amane.hj23.ics@gencat.cat.

Show MeSH
Related in: MedlinePlus