Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons.
Bottom Line: Homologs of each of these genes were previously identified as important in the Drosophila melanogaster dendritic arborization sensory neurons.Our results suggest that RNA processing, mRNA localization, mRNA stability, and translational control are all important mechanisms that contribute to dendrite morphogenesis, and we present a conserved set of RNA-binding proteins that regulate these processes in diverse animal species.Furthermore, homologs of these genes are expressed in the human brain, suggesting that these RNA-binding proteins are candidate regulators of dendrite development in humans.
Affiliation: Department of Molecular Biology, Colorado College, Colorado Springs, Colorado 80903.Show MeSH
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Mentions: We found a statistically significant reduction of dendritic termini in cpb-3, dcr-1, larp-5, mbl-1, mtr-4, set-2, rsp-6, and Y55F3AM.3 mutants relative to the control at all stages (Figure 3A). This finding suggests that these mutants fail to form the appropriate number of terminal branches and that there is neither a delay nor a maintenance defect.
Affiliation: Department of Molecular Biology, Colorado College, Colorado Springs, Colorado 80903.