Global diversity lines - a five-continent reference panel of sequenced Drosophila melanogaster strains.
Bottom Line: Another key feature of these strains is their widespread geographic origin, coming from Beijing, Ithaca, Netherlands, Tasmania, and Zimbabwe.We found 83 segregating inversions among the lines, and as expected these were especially abundant in the African sample.We anticipate that this will make a useful addition to the set of reference D. melanogaster strains, thanks to its geographic structuring and unusually high level of genetic diversity.
Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853.Show MeSH
Related in: MedlinePlus
Mentions: As indicated by the SFS previously, significant heterogeneity in genome-wide nucleotide diversity is observed across all populations (Figure 8). Median genome-wide diversity levels (π) range from ~0.3% (Beijing) to ~0.6% (Zimbabwe); Watterson’s θ ranges from ~0.03% to ~0.07%. Consistent with previous studies, broad-scale patterns of within-genome diversity covary with local recombination intensity and display reduced diversity near the telomeres and centromeres (Figure 8A). In addition, the X chromosomes of all populations—except for Zimbabwe —display a marked reduction in diversity levels as compared with the normally recombining autosomes (excluding chromosome 4).
Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853.