Global diversity lines - a five-continent reference panel of sequenced Drosophila melanogaster strains.
Bottom Line: Another key feature of these strains is their widespread geographic origin, coming from Beijing, Ithaca, Netherlands, Tasmania, and Zimbabwe.We found 83 segregating inversions among the lines, and as expected these were especially abundant in the African sample.We anticipate that this will make a useful addition to the set of reference D. melanogaster strains, thanks to its geographic structuring and unusually high level of genetic diversity.
Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853.Show MeSH
Related in: MedlinePlus
Mentions: A major interest of the field is lineage-specific differentiation and the extent to which such differences might be driven by local adaptation. As a first look into this question we extracted all SNPs that were private to a single population and that also had a relatively high allele frequency (≥20%). Figure 7, A−C plots the counts for these alleles stratified by allele frequency bins. The finding of thousands of population-specific nonsynonymous, synonymous and UTR SNPs is highly unlikely, given a simple island model with the observed FST (these counts ranged from 1387 for Ithaca to 52,079 for Zimbabwe). These initial observations suggest a role for natural selection-driving patterns of differentiation and motivate a more thorough analysis of local adaptation detectable with these data.
Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853.