Global diversity lines - a five-continent reference panel of sequenced Drosophila melanogaster strains.
Bottom Line: Another key feature of these strains is their widespread geographic origin, coming from Beijing, Ithaca, Netherlands, Tasmania, and Zimbabwe.We found 83 segregating inversions among the lines, and as expected these were especially abundant in the African sample.We anticipate that this will make a useful addition to the set of reference D. melanogaster strains, thanks to its geographic structuring and unusually high level of genetic diversity.
Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853.Show MeSH
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Mentions: Another data quality check examined the unfolded SFS for four SNP classes combined across the full dataset and partitioned into an X chromosome set and an autosomal set: (1) nonsynonymous, (2) synonymous, but not fourfold degenerate, (3) intergenic, and (4) a “neutral” class comprised of fourfold degenerate and small intronic SNPs (Figure 6). The number of SNPs (~167,000) was balanced to match the limiting counts from the ‘neutral’ set.
Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853.