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Increased excitability of lateral habenula neurons in adolescent rats following cocaine self-administration.

Neumann PA, Ishikawa M, Otaka M, Huang YH, Schlüter OM, Dong Y - Int. J. Neuropsychopharmacol. (2014)

Bottom Line: However, the mechanisms of this effect are poorly understood.We found two major relevant neuronal subtypes: burst firing neurons and regular spiking neurons.These results may help to explain how cocaine and other drugs negatively impact affect states.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Department (Drs Neumann, Ishikawa, Otaka, and Dong), and Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA (Dr Huang); Molecular Neurobiology, European Neuroscience Institute, Göttingen, Germany (Dr Schlüter). pan23@pitt.edu yandong@pitt.edu.

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Cell types and spiking patterns in the LHb. (a) Example traces showing a typical burst firing (BF) pattern and (b) regular spiking (RS) pattern following depolarizing injections of current. (c-d) Example traces showing typical (c) BF and (d) RS rebound spiking patterns. (e) Chart showing the relative ratios of BF and RS spiking LHb cells during depolarization following saline (BF = 3, RS = 19, total = 22; 6 rats) or cocaine (BF = 4, RS = 19, total = 23; 6 rats) self-administration training. (f) Chart showing the relative ratios of BF and RS rebound spiking patterns in LHb cells following saline (BF = 12, RS = 10, total = 22; 6 rats) or cocaine (BF = 14, RS = 9, total = 23; 6 rats) self-administration training. (g) Example trace showing a typical approximately 5-Hz tonic firing pattern from an LHb cell at rest.
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Figure 3: Cell types and spiking patterns in the LHb. (a) Example traces showing a typical burst firing (BF) pattern and (b) regular spiking (RS) pattern following depolarizing injections of current. (c-d) Example traces showing typical (c) BF and (d) RS rebound spiking patterns. (e) Chart showing the relative ratios of BF and RS spiking LHb cells during depolarization following saline (BF = 3, RS = 19, total = 22; 6 rats) or cocaine (BF = 4, RS = 19, total = 23; 6 rats) self-administration training. (f) Chart showing the relative ratios of BF and RS rebound spiking patterns in LHb cells following saline (BF = 12, RS = 10, total = 22; 6 rats) or cocaine (BF = 14, RS = 9, total = 23; 6 rats) self-administration training. (g) Example trace showing a typical approximately 5-Hz tonic firing pattern from an LHb cell at rest.

Mentions: A survey of LHb cells revealed 2 relevant major neuronal types: burst firing (BF) cells and regular spiking (RS) cells (Figure 3a-b). Continued observation revealed that 3 of 22 recorded cells from saline-treated animals showed clear BF characteristics, while 4 of 23 recorded cells from cocaine-treated animals showed clear BF characteristics (Figure 3e), indicating that cocaine exposure does not shift the population composition of BF/RS cell types in the LHb.


Increased excitability of lateral habenula neurons in adolescent rats following cocaine self-administration.

Neumann PA, Ishikawa M, Otaka M, Huang YH, Schlüter OM, Dong Y - Int. J. Neuropsychopharmacol. (2014)

Cell types and spiking patterns in the LHb. (a) Example traces showing a typical burst firing (BF) pattern and (b) regular spiking (RS) pattern following depolarizing injections of current. (c-d) Example traces showing typical (c) BF and (d) RS rebound spiking patterns. (e) Chart showing the relative ratios of BF and RS spiking LHb cells during depolarization following saline (BF = 3, RS = 19, total = 22; 6 rats) or cocaine (BF = 4, RS = 19, total = 23; 6 rats) self-administration training. (f) Chart showing the relative ratios of BF and RS rebound spiking patterns in LHb cells following saline (BF = 12, RS = 10, total = 22; 6 rats) or cocaine (BF = 14, RS = 9, total = 23; 6 rats) self-administration training. (g) Example trace showing a typical approximately 5-Hz tonic firing pattern from an LHb cell at rest.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390528&req=5

Figure 3: Cell types and spiking patterns in the LHb. (a) Example traces showing a typical burst firing (BF) pattern and (b) regular spiking (RS) pattern following depolarizing injections of current. (c-d) Example traces showing typical (c) BF and (d) RS rebound spiking patterns. (e) Chart showing the relative ratios of BF and RS spiking LHb cells during depolarization following saline (BF = 3, RS = 19, total = 22; 6 rats) or cocaine (BF = 4, RS = 19, total = 23; 6 rats) self-administration training. (f) Chart showing the relative ratios of BF and RS rebound spiking patterns in LHb cells following saline (BF = 12, RS = 10, total = 22; 6 rats) or cocaine (BF = 14, RS = 9, total = 23; 6 rats) self-administration training. (g) Example trace showing a typical approximately 5-Hz tonic firing pattern from an LHb cell at rest.
Mentions: A survey of LHb cells revealed 2 relevant major neuronal types: burst firing (BF) cells and regular spiking (RS) cells (Figure 3a-b). Continued observation revealed that 3 of 22 recorded cells from saline-treated animals showed clear BF characteristics, while 4 of 23 recorded cells from cocaine-treated animals showed clear BF characteristics (Figure 3e), indicating that cocaine exposure does not shift the population composition of BF/RS cell types in the LHb.

Bottom Line: However, the mechanisms of this effect are poorly understood.We found two major relevant neuronal subtypes: burst firing neurons and regular spiking neurons.These results may help to explain how cocaine and other drugs negatively impact affect states.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Department (Drs Neumann, Ishikawa, Otaka, and Dong), and Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA (Dr Huang); Molecular Neurobiology, European Neuroscience Institute, Göttingen, Germany (Dr Schlüter). pan23@pitt.edu yandong@pitt.edu.

Show MeSH
Related in: MedlinePlus